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A case of IgG4-positive ligneous conjunctivitis mistaken for a conjunctival mass
BACKGROUND: Ligneous conjunctivitis (LC) is a rare inflammatory lesion of the conjunctiva with an unknown etiology. It is easily confused with conjunctiva lymphoma or other diseases in clinical diagnosis, and the lesion is very difficult to treat. CASE PRESENTATION: We presented a 41-year-old female...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10308656/ https://www.ncbi.nlm.nih.gov/pubmed/37386507 http://dx.doi.org/10.1186/s13000-023-01366-0 |
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author | Li, Jing Liu, Rui Ren, Tingting Zhang, Hong Ma, Jianmin |
author_facet | Li, Jing Liu, Rui Ren, Tingting Zhang, Hong Ma, Jianmin |
author_sort | Li, Jing |
collection | PubMed |
description | BACKGROUND: Ligneous conjunctivitis (LC) is a rare inflammatory lesion of the conjunctiva with an unknown etiology. It is easily confused with conjunctiva lymphoma or other diseases in clinical diagnosis, and the lesion is very difficult to treat. CASE PRESENTATION: We presented a 41-year-old female patient presented with bilateral conjunctival masses for more than six months. The patient had no contributory history of ocular trauma, family history of tumor and drug allergy. Taking the patient’s clinical and pathological features together, we considered this was a case of IgG4 + LC. Completely surgical resection combined with local glucocorticoid treatment might be effective. CONCLUSIONS: This is a very rare case report of immunoglobulin G4 positive LC with only one published case in literature. The typical manifestations of LC are with the appearance of a hard, fibrin-rich, woody pseudomembranous lesion. A large number of lymphocyte and plasma cell are infiltrated in the pathological tissue. Inflammation of LC may cause immune abnormalities, resulting in IgG4 increasing. |
format | Online Article Text |
id | pubmed-10308656 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-103086562023-06-30 A case of IgG4-positive ligneous conjunctivitis mistaken for a conjunctival mass Li, Jing Liu, Rui Ren, Tingting Zhang, Hong Ma, Jianmin Diagn Pathol Case Report BACKGROUND: Ligneous conjunctivitis (LC) is a rare inflammatory lesion of the conjunctiva with an unknown etiology. It is easily confused with conjunctiva lymphoma or other diseases in clinical diagnosis, and the lesion is very difficult to treat. CASE PRESENTATION: We presented a 41-year-old female patient presented with bilateral conjunctival masses for more than six months. The patient had no contributory history of ocular trauma, family history of tumor and drug allergy. Taking the patient’s clinical and pathological features together, we considered this was a case of IgG4 + LC. Completely surgical resection combined with local glucocorticoid treatment might be effective. CONCLUSIONS: This is a very rare case report of immunoglobulin G4 positive LC with only one published case in literature. The typical manifestations of LC are with the appearance of a hard, fibrin-rich, woody pseudomembranous lesion. A large number of lymphocyte and plasma cell are infiltrated in the pathological tissue. Inflammation of LC may cause immune abnormalities, resulting in IgG4 increasing. BioMed Central 2023-06-29 /pmc/articles/PMC10308656/ /pubmed/37386507 http://dx.doi.org/10.1186/s13000-023-01366-0 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Case Report Li, Jing Liu, Rui Ren, Tingting Zhang, Hong Ma, Jianmin A case of IgG4-positive ligneous conjunctivitis mistaken for a conjunctival mass |
title | A case of IgG4-positive ligneous conjunctivitis mistaken for a conjunctival mass |
title_full | A case of IgG4-positive ligneous conjunctivitis mistaken for a conjunctival mass |
title_fullStr | A case of IgG4-positive ligneous conjunctivitis mistaken for a conjunctival mass |
title_full_unstemmed | A case of IgG4-positive ligneous conjunctivitis mistaken for a conjunctival mass |
title_short | A case of IgG4-positive ligneous conjunctivitis mistaken for a conjunctival mass |
title_sort | case of igg4-positive ligneous conjunctivitis mistaken for a conjunctival mass |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10308656/ https://www.ncbi.nlm.nih.gov/pubmed/37386507 http://dx.doi.org/10.1186/s13000-023-01366-0 |
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