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The homodimer interfaces of costimulatory receptors B7 and CD28 control their engagement and pro-inflammatory signaling

BACKGROUND: The inflammatory response is indispensable for protective immunity, yet microbial pathogens often trigger an excessive response, ‘cytokine storm’, harmful to the host. Full T-cell activation requires interaction of costimulatory receptors B7-1(CD80) and B7-2(CD86) expressed on antigen-pr...

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Detalles Bibliográficos
Autores principales:	Popugailo, Andrey, Rotfogel, Ziv, Levy, Michal, Turgeman, Orli, Hillman, Dalia, Levy, Revital, Arad, Gila, Shpilka, Tomer, Kaempfer, Raymond
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10308680/ https://www.ncbi.nlm.nih.gov/pubmed/37381064 http://dx.doi.org/10.1186/s12929-023-00941-3

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