Increase in power by obtaining 10 or more controls per case when type-1 error is small in large-scale association studies

BACKGROUND: The rule of thumb that there is little gain in statistical power by obtaining more than 4 controls per case, is based on type-1 error α = 0.05. However, association studies that evaluate thousands or millions of associations use smaller α and may have access to plentiful controls. We inv...

Descripción completa

Detalles Bibliográficos
Autores principales: Katki, Hormuzd A., Berndt, Sonja I., Machiela, Mitchell J., Stewart, Douglas R., Garcia-Closas, Montserrat, Kim, Jung, Shi, Jianxin, Yu, Kai, Rothman, Nathaniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10308790/
https://www.ncbi.nlm.nih.gov/pubmed/37386403
http://dx.doi.org/10.1186/s12874-023-01973-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10308790/
https://www.ncbi.nlm.nih.gov/pubmed/37386403
http://dx.doi.org/10.1186/s12874-023-01973-x

Ejemplares similares