High throughput (13)C-metabolic flux analysis of 3-hydroxypropionic acid producing Pichia pastoris reveals limited availability of acetyl-CoA and ATP due to tight control of the glycolytic flux

BACKGROUND: Production of 3-hydroxypropionic acid (3-HP) through the malonyl-CoA pathway has yielded promising results in Pichia pastoris (Komagataella phaffii), demonstrating the potential of this cell factory to produce this platform chemical and other acetyl-CoA-derived products using glycerol as...

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Detalles Bibliográficos
Autores principales: Fina, Albert, Millard, Pierre, Albiol, Joan, Ferrer, Pau, Heux, Stephanie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10308795/
https://www.ncbi.nlm.nih.gov/pubmed/37380999
http://dx.doi.org/10.1186/s12934-023-02123-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10308795/
https://www.ncbi.nlm.nih.gov/pubmed/37380999
http://dx.doi.org/10.1186/s12934-023-02123-0

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