The Cytomegalovirus M35 Protein Directly Binds to the Interferon-β Enhancer and Modulates Transcription of Ifnb1 and Other IRF3-Driven Genes

Induction of type I interferon (IFN) gene expression is among the first lines of cellular defense a virus encounters during primary infection. We previously identified the tegument protein M35 of murine cytomegalovirus (MCMV) as an essential antagonist of this antiviral system, showing that M35 inte...

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Detalles Bibliográficos
Autores principales: Schwanke, Hella, Gonçalves Magalhães, Vladimir, Schmelz, Stefan, Wyler, Emanuel, Hennig, Thomas, Günther, Thomas, Grundhoff, Adam, Dölken, Lars, Landthaler, Markus, van Ham, Marco, Jänsch, Lothar, Büssow, Konrad, van den Heuvel, Joop, Blankenfeldt, Wulf, Friedel, Caroline C., Erhard, Florian, Brinkmann, Melanie M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Virus-Cell Interactions
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10308904/
https://www.ncbi.nlm.nih.gov/pubmed/37289084
http://dx.doi.org/10.1128/jvi.00400-23

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