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Clinicopathological demographics of malignant melanomas of the vulva and vagina in Japan

Malignant vulvar melanoma (VuM) and vaginal melanoma (VaM) represent a unique subgroup of rare malignant melanomas with critical biological properties that differ from other cancers. In Japan, adequate surveys have yet to be conducted. This study aimed to elucidate the clinicopathological demographi...

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Autores principales: Ogata, Dai, Nishio, Shin, Hatta, Naohito, Kaji, Tatsuya, Fujii, Kazuyasu, Mikami, Mikio, Kiyohara, Yoshio, Enomoto, Takayuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10309107/
https://www.ncbi.nlm.nih.gov/pubmed/37162526
http://dx.doi.org/10.1097/CMR.0000000000000894
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author Ogata, Dai
Nishio, Shin
Hatta, Naohito
Kaji, Tatsuya
Fujii, Kazuyasu
Mikami, Mikio
Kiyohara, Yoshio
Enomoto, Takayuki
author_facet Ogata, Dai
Nishio, Shin
Hatta, Naohito
Kaji, Tatsuya
Fujii, Kazuyasu
Mikami, Mikio
Kiyohara, Yoshio
Enomoto, Takayuki
author_sort Ogata, Dai
collection PubMed
description Malignant vulvar melanoma (VuM) and vaginal melanoma (VaM) represent a unique subgroup of rare malignant melanomas with critical biological properties that differ from other cancers. In Japan, adequate surveys have yet to be conducted. This study aimed to elucidate the clinicopathological demographics and outcomes of VuM and VaM in Japan. This retrospective observational study included women with invasive VuM or VaM identified from older medical records in Japan. We collected clinical data and used the Kaplan–Meier method to analyze progression-free survival (PFS) and overall survival (OS). Univariate and multivariate regression models were used to identify factors significantly related to survival. We identified 217 patients, 109 (50.2%) with VuM and 108 (49.8%) with VaM. The median PFS was 16.8 months in patients with VuM [95% confidence interval (CI), 23.1–87.7] and 15.6 months in those with VaM (95% CI, 8.4–12.6). The median OS was 43.9 months (95% CI, 60–138) and 31.1 months (95% CI, 24.8–45.3) in patients with VuM and VaM, respectively. Multivariate analysis showed that a disease stage higher than stage III, based on the American Joint Committee on Cancer (AJCC) guidelines, was associated with poorer PFS [hazard ratio (HR), 2.063; 95% CI, 0.995–4.278] and an unknown surgical margin was the only independent factor influencing OS (HR, 2.188; 95% CI, 1.203–3.977). The overall outcomes of invasive VuM and VaM in Japan remain poor. AJCC staging and surgical margins were significant predictors of survival.
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spelling pubmed-103091072023-06-30 Clinicopathological demographics of malignant melanomas of the vulva and vagina in Japan Ogata, Dai Nishio, Shin Hatta, Naohito Kaji, Tatsuya Fujii, Kazuyasu Mikami, Mikio Kiyohara, Yoshio Enomoto, Takayuki Melanoma Res Original Articles: Clinical Research Malignant vulvar melanoma (VuM) and vaginal melanoma (VaM) represent a unique subgroup of rare malignant melanomas with critical biological properties that differ from other cancers. In Japan, adequate surveys have yet to be conducted. This study aimed to elucidate the clinicopathological demographics and outcomes of VuM and VaM in Japan. This retrospective observational study included women with invasive VuM or VaM identified from older medical records in Japan. We collected clinical data and used the Kaplan–Meier method to analyze progression-free survival (PFS) and overall survival (OS). Univariate and multivariate regression models were used to identify factors significantly related to survival. We identified 217 patients, 109 (50.2%) with VuM and 108 (49.8%) with VaM. The median PFS was 16.8 months in patients with VuM [95% confidence interval (CI), 23.1–87.7] and 15.6 months in those with VaM (95% CI, 8.4–12.6). The median OS was 43.9 months (95% CI, 60–138) and 31.1 months (95% CI, 24.8–45.3) in patients with VuM and VaM, respectively. Multivariate analysis showed that a disease stage higher than stage III, based on the American Joint Committee on Cancer (AJCC) guidelines, was associated with poorer PFS [hazard ratio (HR), 2.063; 95% CI, 0.995–4.278] and an unknown surgical margin was the only independent factor influencing OS (HR, 2.188; 95% CI, 1.203–3.977). The overall outcomes of invasive VuM and VaM in Japan remain poor. AJCC staging and surgical margins were significant predictors of survival. Lippincott Williams & Wilkins 2023-08 2023-05-26 /pmc/articles/PMC10309107/ /pubmed/37162526 http://dx.doi.org/10.1097/CMR.0000000000000894 Text en Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Original Articles: Clinical Research
Ogata, Dai
Nishio, Shin
Hatta, Naohito
Kaji, Tatsuya
Fujii, Kazuyasu
Mikami, Mikio
Kiyohara, Yoshio
Enomoto, Takayuki
Clinicopathological demographics of malignant melanomas of the vulva and vagina in Japan
title Clinicopathological demographics of malignant melanomas of the vulva and vagina in Japan
title_full Clinicopathological demographics of malignant melanomas of the vulva and vagina in Japan
title_fullStr Clinicopathological demographics of malignant melanomas of the vulva and vagina in Japan
title_full_unstemmed Clinicopathological demographics of malignant melanomas of the vulva and vagina in Japan
title_short Clinicopathological demographics of malignant melanomas of the vulva and vagina in Japan
title_sort clinicopathological demographics of malignant melanomas of the vulva and vagina in japan
topic Original Articles: Clinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10309107/
https://www.ncbi.nlm.nih.gov/pubmed/37162526
http://dx.doi.org/10.1097/CMR.0000000000000894
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