Cargando…
Characterization of Placental Infection by Zika Virus in Humans: A Review of the Literature
Objective The aim of the current review is to present a systematic evaluation of reported human placental findings in cases of zika virus (ZIKV) infection. Data sources We reviewed the EMBASE, PUBMED, and SCIELO databases until June 2019, without language restrictions. Selection of studies The se...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Thieme Revinter Publicações Ltda
2020
|
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10309222/ https://www.ncbi.nlm.nih.gov/pubmed/32559805 http://dx.doi.org/10.1055/s-0040-1712126 |
_version_ | 1785066404057186304 |
---|---|
author | Venceslau, Emanuella Meneses Guida, José Paulo Amaral, Eliana Modena, José Luis Proença Costa, Maria Laura |
author_facet | Venceslau, Emanuella Meneses Guida, José Paulo Amaral, Eliana Modena, José Luis Proença Costa, Maria Laura |
author_sort | Venceslau, Emanuella Meneses |
collection | PubMed |
description | Objective The aim of the current review is to present a systematic evaluation of reported human placental findings in cases of zika virus (ZIKV) infection. Data sources We reviewed the EMBASE, PUBMED, and SCIELO databases until June 2019, without language restrictions. Selection of studies The search terms placenta AND zika virus were used. The inclusion criteria of the studies were studies that reported placental findings in humans. Experimental studies, reviews, notes or editorials were excluded. A total of 436 studies were retrieved; after duplicate exclusion, 243 articles had their titles screened, and 128 had their abstract read; of those, 32 were included in the final analysis (18 case reports, 10 case series, and 4 cohorts) Data collection We collected data concerning the author, year of publication, study design, number of participants, number of placental samples, onset of symptoms, perinatal outcomes, and main findings on histological analysis. Data synthesis The placental pathologic findings were described as mild and nonspecific, similar to those of other placental infections, including chronic placentitis, chronic villitis, increased Hofbauer cells, irregular fibrin deposits, increased mononuclear cells in the villus stroma, villous immaturity, edema, hypervascularization, stromal fibrosis, calcification, and focal necrosis of syncytiotrophoblasts. Conclusion Zika infection presents unspecific placental findings, similar to other infections in the toxoplasmosis, other agents, rubella, cytomegalovirus, and herpes (TORCH)group. Characterizing and standardizing placental findings after zika virus infection is key to understanding the mechanisms of congenital diseases. |
format | Online Article Text |
id | pubmed-10309222 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Thieme Revinter Publicações Ltda |
record_format | MEDLINE/PubMed |
spelling | pubmed-103092222023-07-27 Characterization of Placental Infection by Zika Virus in Humans: A Review of the Literature Venceslau, Emanuella Meneses Guida, José Paulo Amaral, Eliana Modena, José Luis Proença Costa, Maria Laura Rev Bras Ginecol Obstet Objective The aim of the current review is to present a systematic evaluation of reported human placental findings in cases of zika virus (ZIKV) infection. Data sources We reviewed the EMBASE, PUBMED, and SCIELO databases until June 2019, without language restrictions. Selection of studies The search terms placenta AND zika virus were used. The inclusion criteria of the studies were studies that reported placental findings in humans. Experimental studies, reviews, notes or editorials were excluded. A total of 436 studies were retrieved; after duplicate exclusion, 243 articles had their titles screened, and 128 had their abstract read; of those, 32 were included in the final analysis (18 case reports, 10 case series, and 4 cohorts) Data collection We collected data concerning the author, year of publication, study design, number of participants, number of placental samples, onset of symptoms, perinatal outcomes, and main findings on histological analysis. Data synthesis The placental pathologic findings were described as mild and nonspecific, similar to those of other placental infections, including chronic placentitis, chronic villitis, increased Hofbauer cells, irregular fibrin deposits, increased mononuclear cells in the villus stroma, villous immaturity, edema, hypervascularization, stromal fibrosis, calcification, and focal necrosis of syncytiotrophoblasts. Conclusion Zika infection presents unspecific placental findings, similar to other infections in the toxoplasmosis, other agents, rubella, cytomegalovirus, and herpes (TORCH)group. Characterizing and standardizing placental findings after zika virus infection is key to understanding the mechanisms of congenital diseases. Thieme Revinter Publicações Ltda 2020-06-19 2020-09 /pmc/articles/PMC10309222/ /pubmed/32559805 http://dx.doi.org/10.1055/s-0040-1712126 Text en The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. ( https://creativecommons.org/licenses/by/4.0/ ). https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Venceslau, Emanuella Meneses Guida, José Paulo Amaral, Eliana Modena, José Luis Proença Costa, Maria Laura Characterization of Placental Infection by Zika Virus in Humans: A Review of the Literature |
title | Characterization of Placental Infection by Zika Virus in Humans: A Review of the Literature |
title_full | Characterization of Placental Infection by Zika Virus in Humans: A Review of the Literature |
title_fullStr | Characterization of Placental Infection by Zika Virus in Humans: A Review of the Literature |
title_full_unstemmed | Characterization of Placental Infection by Zika Virus in Humans: A Review of the Literature |
title_short | Characterization of Placental Infection by Zika Virus in Humans: A Review of the Literature |
title_sort | characterization of placental infection by zika virus in humans: a review of the literature |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10309222/ https://www.ncbi.nlm.nih.gov/pubmed/32559805 http://dx.doi.org/10.1055/s-0040-1712126 |
work_keys_str_mv | AT venceslauemanuellameneses characterizationofplacentalinfectionbyzikavirusinhumansareviewoftheliterature AT guidajosepaulo characterizationofplacentalinfectionbyzikavirusinhumansareviewoftheliterature AT amaraleliana characterizationofplacentalinfectionbyzikavirusinhumansareviewoftheliterature AT modenajoseluisproenca characterizationofplacentalinfectionbyzikavirusinhumansareviewoftheliterature AT costamarialaura characterizationofplacentalinfectionbyzikavirusinhumansareviewoftheliterature |