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Assessment of Metalloproteinase Matrix 9 (MMP9) Gene Polymorphisms Risk Factors for Pelvic Organ Prolapse in the Brazilian Population
Objective To evaluate the C-1562T matrix metalloproteinase 9 (MMP9) gene polymorphisms as risk factors related to the occurrence of pelvic organ prolapse (POP) and to identify the clinical variables associated with the occurrence of the disease. Epidemiological studies of risk factors for POP do not...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Thieme Revinter Publicações Ltda
2019
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10309288/ https://www.ncbi.nlm.nih.gov/pubmed/30939607 http://dx.doi.org/10.1055/s-0039-1681112 |
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author | Ghersel, Frederico Rezende Souto, Ricardo Peres Gonzales, Ester Wilma Pacheco Paulo, Denise Souza Fernandes, César Eduardo Oliveira, Emerson |
author_facet | Ghersel, Frederico Rezende Souto, Ricardo Peres Gonzales, Ester Wilma Pacheco Paulo, Denise Souza Fernandes, César Eduardo Oliveira, Emerson |
author_sort | Ghersel, Frederico Rezende |
collection | PubMed |
description | Objective To evaluate the C-1562T matrix metalloproteinase 9 (MMP9) gene polymorphisms as risk factors related to the occurrence of pelvic organ prolapse (POP) and to identify the clinical variables associated with the occurrence of the disease. Epidemiological studies of risk factors for POP do not explain why nulliparous women with no known risk factors also develop POP. Therefore, genetic factors may be involved. Methods Cohort study with 86 women with symptomatic POP (cases), and 158 women without a prior or current diagnosis of this disorder (controls). The groups were analyzed for the presence of MMP9 gene polymorphisms. Genotyping was performed using polymerase chain reaction (PCR) with DNA obtained from a peripheral venous puncture of both groups. Results There were no differences between the cases and controls even when we grouped the mutant homozygous and heterozygous genotypes. The analysis of patients with a complete absence of POP versus patients with total POP also showed no statistically significant differences. Age and home birth were found to be independent risk factors for POP. Conclusions There were no statistically significant differences in the C-1562T MMP9 polymorphisms between the cases and controls in Brazilian women. |
format | Online Article Text |
id | pubmed-10309288 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Thieme Revinter Publicações Ltda |
record_format | MEDLINE/PubMed |
spelling | pubmed-103092882023-07-27 Assessment of Metalloproteinase Matrix 9 (MMP9) Gene Polymorphisms Risk Factors for Pelvic Organ Prolapse in the Brazilian Population Ghersel, Frederico Rezende Souto, Ricardo Peres Gonzales, Ester Wilma Pacheco Paulo, Denise Souza Fernandes, César Eduardo Oliveira, Emerson Rev Bras Ginecol Obstet Objective To evaluate the C-1562T matrix metalloproteinase 9 (MMP9) gene polymorphisms as risk factors related to the occurrence of pelvic organ prolapse (POP) and to identify the clinical variables associated with the occurrence of the disease. Epidemiological studies of risk factors for POP do not explain why nulliparous women with no known risk factors also develop POP. Therefore, genetic factors may be involved. Methods Cohort study with 86 women with symptomatic POP (cases), and 158 women without a prior or current diagnosis of this disorder (controls). The groups were analyzed for the presence of MMP9 gene polymorphisms. Genotyping was performed using polymerase chain reaction (PCR) with DNA obtained from a peripheral venous puncture of both groups. Results There were no differences between the cases and controls even when we grouped the mutant homozygous and heterozygous genotypes. The analysis of patients with a complete absence of POP versus patients with total POP also showed no statistically significant differences. Age and home birth were found to be independent risk factors for POP. Conclusions There were no statistically significant differences in the C-1562T MMP9 polymorphisms between the cases and controls in Brazilian women. Thieme Revinter Publicações Ltda 2019-04-02 2019-03 /pmc/articles/PMC10309288/ /pubmed/30939607 http://dx.doi.org/10.1055/s-0039-1681112 Text en https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Ghersel, Frederico Rezende Souto, Ricardo Peres Gonzales, Ester Wilma Pacheco Paulo, Denise Souza Fernandes, César Eduardo Oliveira, Emerson Assessment of Metalloproteinase Matrix 9 (MMP9) Gene Polymorphisms Risk Factors for Pelvic Organ Prolapse in the Brazilian Population |
title | Assessment of Metalloproteinase Matrix 9 (MMP9) Gene Polymorphisms Risk Factors for Pelvic Organ Prolapse in the Brazilian Population |
title_full | Assessment of Metalloproteinase Matrix 9 (MMP9) Gene Polymorphisms Risk Factors for Pelvic Organ Prolapse in the Brazilian Population |
title_fullStr | Assessment of Metalloproteinase Matrix 9 (MMP9) Gene Polymorphisms Risk Factors for Pelvic Organ Prolapse in the Brazilian Population |
title_full_unstemmed | Assessment of Metalloproteinase Matrix 9 (MMP9) Gene Polymorphisms Risk Factors for Pelvic Organ Prolapse in the Brazilian Population |
title_short | Assessment of Metalloproteinase Matrix 9 (MMP9) Gene Polymorphisms Risk Factors for Pelvic Organ Prolapse in the Brazilian Population |
title_sort | assessment of metalloproteinase matrix 9 (mmp9) gene polymorphisms risk factors for pelvic organ prolapse in the brazilian population |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10309288/ https://www.ncbi.nlm.nih.gov/pubmed/30939607 http://dx.doi.org/10.1055/s-0039-1681112 |
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