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Evaluation of Probably Benign Adnexal Masses in Postmenopausal Women

Background Preoperatively identification of malignancy potential of a postmenopausal adnexal masses is important. Aim To evaluate the effectiveness of the Risk of Malignancy Index-2 in presumably benign adnexal masses in postmenopausal women. Study Design Retrospective, observational study. Methods ...

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Autores principales: Karakaya, Burcu Kisa, Ozgu, Emre, Kansu, Hatice Celik, Evliyaoglu, Ozlem, Sarikaya, Esma, Coskun, Bugra, Erkaya, Salim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Thieme Revinter Publicações Ltda 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10309342/
https://www.ncbi.nlm.nih.gov/pubmed/28346954
http://dx.doi.org/10.1055/s-0037-1601454
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author Karakaya, Burcu Kisa
Ozgu, Emre
Kansu, Hatice Celik
Evliyaoglu, Ozlem
Sarikaya, Esma
Coskun, Bugra
Erkaya, Salim
author_facet Karakaya, Burcu Kisa
Ozgu, Emre
Kansu, Hatice Celik
Evliyaoglu, Ozlem
Sarikaya, Esma
Coskun, Bugra
Erkaya, Salim
author_sort Karakaya, Burcu Kisa
collection PubMed
description Background Preoperatively identification of malignancy potential of a postmenopausal adnexal masses is important. Aim To evaluate the effectiveness of the Risk of Malignancy Index-2 in presumably benign adnexal masses in postmenopausal women. Study Design Retrospective, observational study. Methods 119 women with postmenopausal adnexal masses with a preliminary diagnosis of benign tumors according to the Risk of Malignancy Index-2 were included. Age, duration of menopause, ultrasonographic findings, and serum CA-125 levels were recorded preoperatively. The definitive diagnosis was based on postoperative histopathological examination. Results Of 119 adnexal mass, 10 were malignant and 109 were benign. There was no statistically significant difference with regard to age and tumor size between the groups. The two significant ultrasonographic parameter between groups were the presence of solid area in the mass and bilaterality. Moreover, if the cut off point for serum CA-125 was adjusted to 14.75 IU/mL according to ROC curve, a sensitivity value of 80% and a specificity value of 72% could be achieved to discriminate benign and malign cysts. Conclusion In the differential diagnosis of benign and malignant adnexal masses in postmenopausal women, the presence of a solid component, bilaterallity based on ultrasonography and high CA-125 values may be used as discriminative criteria. There is no direct relation between the size of the adnexal mass and malignancy potential. Therefore, in the malignancy indexes of postmenopausal women, we recommend lower cut-off values of CA-125 to increase the sensitivity of preoperative evaluation tests without having a great impact on negative predictive values.
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spelling pubmed-103093422023-07-27 Evaluation of Probably Benign Adnexal Masses in Postmenopausal Women Karakaya, Burcu Kisa Ozgu, Emre Kansu, Hatice Celik Evliyaoglu, Ozlem Sarikaya, Esma Coskun, Bugra Erkaya, Salim Rev Bras Ginecol Obstet Background Preoperatively identification of malignancy potential of a postmenopausal adnexal masses is important. Aim To evaluate the effectiveness of the Risk of Malignancy Index-2 in presumably benign adnexal masses in postmenopausal women. Study Design Retrospective, observational study. Methods 119 women with postmenopausal adnexal masses with a preliminary diagnosis of benign tumors according to the Risk of Malignancy Index-2 were included. Age, duration of menopause, ultrasonographic findings, and serum CA-125 levels were recorded preoperatively. The definitive diagnosis was based on postoperative histopathological examination. Results Of 119 adnexal mass, 10 were malignant and 109 were benign. There was no statistically significant difference with regard to age and tumor size between the groups. The two significant ultrasonographic parameter between groups were the presence of solid area in the mass and bilaterality. Moreover, if the cut off point for serum CA-125 was adjusted to 14.75 IU/mL according to ROC curve, a sensitivity value of 80% and a specificity value of 72% could be achieved to discriminate benign and malign cysts. Conclusion In the differential diagnosis of benign and malignant adnexal masses in postmenopausal women, the presence of a solid component, bilaterallity based on ultrasonography and high CA-125 values may be used as discriminative criteria. There is no direct relation between the size of the adnexal mass and malignancy potential. Therefore, in the malignancy indexes of postmenopausal women, we recommend lower cut-off values of CA-125 to increase the sensitivity of preoperative evaluation tests without having a great impact on negative predictive values. Thieme Revinter Publicações Ltda 2017-03-27 2017-05 /pmc/articles/PMC10309342/ /pubmed/28346954 http://dx.doi.org/10.1055/s-0037-1601454 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License, which permits unrestricted reproduction and distribution, for non-commercial purposes only; and use and reproduction, but not distribution, of adapted material for non-commercial purposes only, provided the original work is properly cited.
spellingShingle Karakaya, Burcu Kisa
Ozgu, Emre
Kansu, Hatice Celik
Evliyaoglu, Ozlem
Sarikaya, Esma
Coskun, Bugra
Erkaya, Salim
Evaluation of Probably Benign Adnexal Masses in Postmenopausal Women
title Evaluation of Probably Benign Adnexal Masses in Postmenopausal Women
title_full Evaluation of Probably Benign Adnexal Masses in Postmenopausal Women
title_fullStr Evaluation of Probably Benign Adnexal Masses in Postmenopausal Women
title_full_unstemmed Evaluation of Probably Benign Adnexal Masses in Postmenopausal Women
title_short Evaluation of Probably Benign Adnexal Masses in Postmenopausal Women
title_sort evaluation of probably benign adnexal masses in postmenopausal women
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10309342/
https://www.ncbi.nlm.nih.gov/pubmed/28346954
http://dx.doi.org/10.1055/s-0037-1601454
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