Cargando…

A Critical Review on Obstetric Follow-up of Women Affected by Systemic Lupus Erythematosus

Objective To review the existing recommendations on the prenatal care of women with systemic lupus erythematosus (SLE), based on currently available scientific evidence. Methods An integrative review was performed by two independent researchers, based on the literature available in the MEDLINE (via...

Descripción completa

Detalles Bibliográficos
Autores principales: Pastore, Danilo Eduardo Abib, Costa, Maria Laura, Parpinelli, Mary Angela, Surita, Fernanda Garanhani
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Thieme Revinter Publicações Ltda 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10309370/
https://www.ncbi.nlm.nih.gov/pubmed/29702718
http://dx.doi.org/10.1055/s-0038-1625951
_version_ 1785066433781170176
author Pastore, Danilo Eduardo Abib
Costa, Maria Laura
Parpinelli, Mary Angela
Surita, Fernanda Garanhani
author_facet Pastore, Danilo Eduardo Abib
Costa, Maria Laura
Parpinelli, Mary Angela
Surita, Fernanda Garanhani
author_sort Pastore, Danilo Eduardo Abib
collection PubMed
description Objective To review the existing recommendations on the prenatal care of women with systemic lupus erythematosus (SLE), based on currently available scientific evidence. Methods An integrative review was performed by two independent researchers, based on the literature available in the MEDLINE (via PubMed), EMBASE and The Cochrane Library databases, using the medical subject headings (MeSH) terms “systemic lupus erythematosus” AND “high-risk pregnancy” OR “prenatal care.” Studies published in English between 2007 and 2017 were included; experimental studies and case reports were excluded. In cases of disagreement regarding the inclusion of studies, a third senior researcher was consulted. Forty titles were initially identified; four duplicates were excluded. After reading the abstracts, 7 were further excluded and 29 were selected for a full-text evaluation. Results Systemic lupus erythematosus flares, preeclampsia, gestation loss, preterm birth, fetal growth restriction and neonatal lupus syndromes (mainly congenital heart-block) were the major complications described. The multidisciplinary team should adopt a specific monitoring, with particular therapeutic protocols. There are safe and effective drug options that should be prescribed for a good control of SLE activity. Conclusion Pregnant women with SLE present an increased risk for maternal complications, pregnancy loss and other adverse outcomes. The disease activity may worsen and, thereby, increase the risk of other maternal-fetal complications. Thus, maintaining an adequate control of disease activity and treating flares quickly should be a central goal during prenatal care.
format Online
Article
Text
id pubmed-10309370
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Thieme Revinter Publicações Ltda
record_format MEDLINE/PubMed
spelling pubmed-103093702023-07-27 A Critical Review on Obstetric Follow-up of Women Affected by Systemic Lupus Erythematosus Pastore, Danilo Eduardo Abib Costa, Maria Laura Parpinelli, Mary Angela Surita, Fernanda Garanhani Rev Bras Ginecol Obstet Objective To review the existing recommendations on the prenatal care of women with systemic lupus erythematosus (SLE), based on currently available scientific evidence. Methods An integrative review was performed by two independent researchers, based on the literature available in the MEDLINE (via PubMed), EMBASE and The Cochrane Library databases, using the medical subject headings (MeSH) terms “systemic lupus erythematosus” AND “high-risk pregnancy” OR “prenatal care.” Studies published in English between 2007 and 2017 were included; experimental studies and case reports were excluded. In cases of disagreement regarding the inclusion of studies, a third senior researcher was consulted. Forty titles were initially identified; four duplicates were excluded. After reading the abstracts, 7 were further excluded and 29 were selected for a full-text evaluation. Results Systemic lupus erythematosus flares, preeclampsia, gestation loss, preterm birth, fetal growth restriction and neonatal lupus syndromes (mainly congenital heart-block) were the major complications described. The multidisciplinary team should adopt a specific monitoring, with particular therapeutic protocols. There are safe and effective drug options that should be prescribed for a good control of SLE activity. Conclusion Pregnant women with SLE present an increased risk for maternal complications, pregnancy loss and other adverse outcomes. The disease activity may worsen and, thereby, increase the risk of other maternal-fetal complications. Thus, maintaining an adequate control of disease activity and treating flares quickly should be a central goal during prenatal care. Thieme Revinter Publicações Ltda 2018-04-27 2018-04 /pmc/articles/PMC10309370/ /pubmed/29702718 http://dx.doi.org/10.1055/s-0038-1625951 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License, which permits unrestricted reproduction and distribution, for non-commercial purposes only; and use and reproduction, but not distribution, of adapted material for non-commercial purposes only, provided the original work is properly cited.
spellingShingle Pastore, Danilo Eduardo Abib
Costa, Maria Laura
Parpinelli, Mary Angela
Surita, Fernanda Garanhani
A Critical Review on Obstetric Follow-up of Women Affected by Systemic Lupus Erythematosus
title A Critical Review on Obstetric Follow-up of Women Affected by Systemic Lupus Erythematosus
title_full A Critical Review on Obstetric Follow-up of Women Affected by Systemic Lupus Erythematosus
title_fullStr A Critical Review on Obstetric Follow-up of Women Affected by Systemic Lupus Erythematosus
title_full_unstemmed A Critical Review on Obstetric Follow-up of Women Affected by Systemic Lupus Erythematosus
title_short A Critical Review on Obstetric Follow-up of Women Affected by Systemic Lupus Erythematosus
title_sort critical review on obstetric follow-up of women affected by systemic lupus erythematosus
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10309370/
https://www.ncbi.nlm.nih.gov/pubmed/29702718
http://dx.doi.org/10.1055/s-0038-1625951
work_keys_str_mv AT pastoredaniloeduardoabib acriticalreviewonobstetricfollowupofwomenaffectedbysystemiclupuserythematosus
AT costamarialaura acriticalreviewonobstetricfollowupofwomenaffectedbysystemiclupuserythematosus
AT parpinellimaryangela acriticalreviewonobstetricfollowupofwomenaffectedbysystemiclupuserythematosus
AT suritafernandagaranhani acriticalreviewonobstetricfollowupofwomenaffectedbysystemiclupuserythematosus
AT pastoredaniloeduardoabib criticalreviewonobstetricfollowupofwomenaffectedbysystemiclupuserythematosus
AT costamarialaura criticalreviewonobstetricfollowupofwomenaffectedbysystemiclupuserythematosus
AT parpinellimaryangela criticalreviewonobstetricfollowupofwomenaffectedbysystemiclupuserythematosus
AT suritafernandagaranhani criticalreviewonobstetricfollowupofwomenaffectedbysystemiclupuserythematosus