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A Critical Review on Obstetric Follow-up of Women Affected by Systemic Lupus Erythematosus
Objective To review the existing recommendations on the prenatal care of women with systemic lupus erythematosus (SLE), based on currently available scientific evidence. Methods An integrative review was performed by two independent researchers, based on the literature available in the MEDLINE (via...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Thieme Revinter Publicações Ltda
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10309370/ https://www.ncbi.nlm.nih.gov/pubmed/29702718 http://dx.doi.org/10.1055/s-0038-1625951 |
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author | Pastore, Danilo Eduardo Abib Costa, Maria Laura Parpinelli, Mary Angela Surita, Fernanda Garanhani |
author_facet | Pastore, Danilo Eduardo Abib Costa, Maria Laura Parpinelli, Mary Angela Surita, Fernanda Garanhani |
author_sort | Pastore, Danilo Eduardo Abib |
collection | PubMed |
description | Objective To review the existing recommendations on the prenatal care of women with systemic lupus erythematosus (SLE), based on currently available scientific evidence. Methods An integrative review was performed by two independent researchers, based on the literature available in the MEDLINE (via PubMed), EMBASE and The Cochrane Library databases, using the medical subject headings (MeSH) terms “systemic lupus erythematosus” AND “high-risk pregnancy” OR “prenatal care.” Studies published in English between 2007 and 2017 were included; experimental studies and case reports were excluded. In cases of disagreement regarding the inclusion of studies, a third senior researcher was consulted. Forty titles were initially identified; four duplicates were excluded. After reading the abstracts, 7 were further excluded and 29 were selected for a full-text evaluation. Results Systemic lupus erythematosus flares, preeclampsia, gestation loss, preterm birth, fetal growth restriction and neonatal lupus syndromes (mainly congenital heart-block) were the major complications described. The multidisciplinary team should adopt a specific monitoring, with particular therapeutic protocols. There are safe and effective drug options that should be prescribed for a good control of SLE activity. Conclusion Pregnant women with SLE present an increased risk for maternal complications, pregnancy loss and other adverse outcomes. The disease activity may worsen and, thereby, increase the risk of other maternal-fetal complications. Thus, maintaining an adequate control of disease activity and treating flares quickly should be a central goal during prenatal care. |
format | Online Article Text |
id | pubmed-10309370 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Thieme Revinter Publicações Ltda |
record_format | MEDLINE/PubMed |
spelling | pubmed-103093702023-07-27 A Critical Review on Obstetric Follow-up of Women Affected by Systemic Lupus Erythematosus Pastore, Danilo Eduardo Abib Costa, Maria Laura Parpinelli, Mary Angela Surita, Fernanda Garanhani Rev Bras Ginecol Obstet Objective To review the existing recommendations on the prenatal care of women with systemic lupus erythematosus (SLE), based on currently available scientific evidence. Methods An integrative review was performed by two independent researchers, based on the literature available in the MEDLINE (via PubMed), EMBASE and The Cochrane Library databases, using the medical subject headings (MeSH) terms “systemic lupus erythematosus” AND “high-risk pregnancy” OR “prenatal care.” Studies published in English between 2007 and 2017 were included; experimental studies and case reports were excluded. In cases of disagreement regarding the inclusion of studies, a third senior researcher was consulted. Forty titles were initially identified; four duplicates were excluded. After reading the abstracts, 7 were further excluded and 29 were selected for a full-text evaluation. Results Systemic lupus erythematosus flares, preeclampsia, gestation loss, preterm birth, fetal growth restriction and neonatal lupus syndromes (mainly congenital heart-block) were the major complications described. The multidisciplinary team should adopt a specific monitoring, with particular therapeutic protocols. There are safe and effective drug options that should be prescribed for a good control of SLE activity. Conclusion Pregnant women with SLE present an increased risk for maternal complications, pregnancy loss and other adverse outcomes. The disease activity may worsen and, thereby, increase the risk of other maternal-fetal complications. Thus, maintaining an adequate control of disease activity and treating flares quickly should be a central goal during prenatal care. Thieme Revinter Publicações Ltda 2018-04-27 2018-04 /pmc/articles/PMC10309370/ /pubmed/29702718 http://dx.doi.org/10.1055/s-0038-1625951 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License, which permits unrestricted reproduction and distribution, for non-commercial purposes only; and use and reproduction, but not distribution, of adapted material for non-commercial purposes only, provided the original work is properly cited. |
spellingShingle | Pastore, Danilo Eduardo Abib Costa, Maria Laura Parpinelli, Mary Angela Surita, Fernanda Garanhani A Critical Review on Obstetric Follow-up of Women Affected by Systemic Lupus Erythematosus |
title | A Critical Review on Obstetric Follow-up of Women Affected by Systemic Lupus Erythematosus |
title_full | A Critical Review on Obstetric Follow-up of Women Affected by Systemic Lupus Erythematosus |
title_fullStr | A Critical Review on Obstetric Follow-up of Women Affected by Systemic Lupus Erythematosus |
title_full_unstemmed | A Critical Review on Obstetric Follow-up of Women Affected by Systemic Lupus Erythematosus |
title_short | A Critical Review on Obstetric Follow-up of Women Affected by Systemic Lupus Erythematosus |
title_sort | critical review on obstetric follow-up of women affected by systemic lupus erythematosus |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10309370/ https://www.ncbi.nlm.nih.gov/pubmed/29702718 http://dx.doi.org/10.1055/s-0038-1625951 |
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