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Profile of Reproductive Issues Associated with Different Sickle Cell Disease Genotypes

Purpose To describe the reproductive variables associated with different sickle cell disease (SCD) genotypes and the influence of contraceptive methods on acute painful episodes among the women with the homozygous hemoglobin S (HbSS) genotype. Methods A cross-sectional study was conducted between Se...

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Autores principales: Carvalho, Flávia Anchielle, Souza, Ariani Impieri, Ferreira, Ana Laura Carneiro Gomes, Neto, Simone da Silva, Oliveira, Ana Carolina Pessoa de Lima, Gomes, Maria Luiza Rodrigues Pinheiro, Costa, Manuela Freire Hazin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Thieme Revinter Publicações Ltda 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10309491/
https://www.ncbi.nlm.nih.gov/pubmed/28683515
http://dx.doi.org/10.1055/s-0037-1604179
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author Carvalho, Flávia Anchielle
Souza, Ariani Impieri
Ferreira, Ana Laura Carneiro Gomes
Neto, Simone da Silva
Oliveira, Ana Carolina Pessoa de Lima
Gomes, Maria Luiza Rodrigues Pinheiro
Costa, Manuela Freire Hazin
author_facet Carvalho, Flávia Anchielle
Souza, Ariani Impieri
Ferreira, Ana Laura Carneiro Gomes
Neto, Simone da Silva
Oliveira, Ana Carolina Pessoa de Lima
Gomes, Maria Luiza Rodrigues Pinheiro
Costa, Manuela Freire Hazin
author_sort Carvalho, Flávia Anchielle
collection PubMed
description Purpose To describe the reproductive variables associated with different sickle cell disease (SCD) genotypes and the influence of contraceptive methods on acute painful episodes among the women with the homozygous hemoglobin S (HbSS) genotype. Methods A cross-sectional study was conducted between September of 2015 and April of 2016 on 158 women afflicted with SCD admitted to a hematology center in the Northeast of Brazil. The reproduction-associated variables of different SCD genotypes were assessed using the analysis of variance (ANOVA) test to compare means, and the Kruskal-Wallis test to compare medians. The association between the contraceptive method and the acute painful episodes was evaluated by the Chi-square test. Results The mean age of women with SCD was 28.3 years and 86.6% were mixed or of African-American ethnicity. With respect to the genotypes, 134 women (84.8%) had HbSS genotype, 12 women (7.6%) had hemoglobin SC (HbSC) disease genotype, and 12 (7.6%) were identified with hemoglobinopathy S-beta (S-β) thalassemia. The mean age of HbSS diagnosis was lower than that of HbSC disease, the less severe form of SCD (p < 0.001). The mean age of menarche was 14.8 ± 1.8 years for HbSS and 12.7 ± 1.5 years for HbSC (p < 0.001). Among women with HbSS who used progestin-only contraception, 16.6% had more than 4 acute painful episodes per year. There was no statistically significant difference when compared with other contraceptive methods. Conclusion With respect to reproduction-associated variables, only the age of the menarche showed delay in HbSS when compared with HbSC. The contraceptive method used was not associated with the frequency of acute painful episodes among the HbSS women.
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spelling pubmed-103094912023-07-27 Profile of Reproductive Issues Associated with Different Sickle Cell Disease Genotypes Carvalho, Flávia Anchielle Souza, Ariani Impieri Ferreira, Ana Laura Carneiro Gomes Neto, Simone da Silva Oliveira, Ana Carolina Pessoa de Lima Gomes, Maria Luiza Rodrigues Pinheiro Costa, Manuela Freire Hazin Rev Bras Ginecol Obstet Purpose To describe the reproductive variables associated with different sickle cell disease (SCD) genotypes and the influence of contraceptive methods on acute painful episodes among the women with the homozygous hemoglobin S (HbSS) genotype. Methods A cross-sectional study was conducted between September of 2015 and April of 2016 on 158 women afflicted with SCD admitted to a hematology center in the Northeast of Brazil. The reproduction-associated variables of different SCD genotypes were assessed using the analysis of variance (ANOVA) test to compare means, and the Kruskal-Wallis test to compare medians. The association between the contraceptive method and the acute painful episodes was evaluated by the Chi-square test. Results The mean age of women with SCD was 28.3 years and 86.6% were mixed or of African-American ethnicity. With respect to the genotypes, 134 women (84.8%) had HbSS genotype, 12 women (7.6%) had hemoglobin SC (HbSC) disease genotype, and 12 (7.6%) were identified with hemoglobinopathy S-beta (S-β) thalassemia. The mean age of HbSS diagnosis was lower than that of HbSC disease, the less severe form of SCD (p < 0.001). The mean age of menarche was 14.8 ± 1.8 years for HbSS and 12.7 ± 1.5 years for HbSC (p < 0.001). Among women with HbSS who used progestin-only contraception, 16.6% had more than 4 acute painful episodes per year. There was no statistically significant difference when compared with other contraceptive methods. Conclusion With respect to reproduction-associated variables, only the age of the menarche showed delay in HbSS when compared with HbSC. The contraceptive method used was not associated with the frequency of acute painful episodes among the HbSS women. Thieme Revinter Publicações Ltda 2017-07-06 2017-08 /pmc/articles/PMC10309491/ /pubmed/28683515 http://dx.doi.org/10.1055/s-0037-1604179 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License, which permits unrestricted reproduction and distribution, for non-commercial purposes only; and use and reproduction, but not distribution, of adapted material for non-commercial purposes only, provided the original work is properly cited.
spellingShingle Carvalho, Flávia Anchielle
Souza, Ariani Impieri
Ferreira, Ana Laura Carneiro Gomes
Neto, Simone da Silva
Oliveira, Ana Carolina Pessoa de Lima
Gomes, Maria Luiza Rodrigues Pinheiro
Costa, Manuela Freire Hazin
Profile of Reproductive Issues Associated with Different Sickle Cell Disease Genotypes
title Profile of Reproductive Issues Associated with Different Sickle Cell Disease Genotypes
title_full Profile of Reproductive Issues Associated with Different Sickle Cell Disease Genotypes
title_fullStr Profile of Reproductive Issues Associated with Different Sickle Cell Disease Genotypes
title_full_unstemmed Profile of Reproductive Issues Associated with Different Sickle Cell Disease Genotypes
title_short Profile of Reproductive Issues Associated with Different Sickle Cell Disease Genotypes
title_sort profile of reproductive issues associated with different sickle cell disease genotypes
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10309491/
https://www.ncbi.nlm.nih.gov/pubmed/28683515
http://dx.doi.org/10.1055/s-0037-1604179
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