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Roles of microRNA-192 in diabetic nephropathy: the clinical applications and mechanisms of action

Diabetic nephropathy (DN) is one of the most common and intractable microvascular complications of diabetes worldwide, serving as the main cause of terminal renal disease. Due to the lack of early specific symptoms and diagnostic markers, DN severely threatens the sufferer’s life. MicroRNA-192 (miR-...

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Autores principales: Wan, Xiaoqing, Liao, Jian, Lai, Hongting, Zhang, Shilong, Cui, Jianling, Chen, Chunyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10309560/
https://www.ncbi.nlm.nih.gov/pubmed/37396169
http://dx.doi.org/10.3389/fendo.2023.1179161
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author Wan, Xiaoqing
Liao, Jian
Lai, Hongting
Zhang, Shilong
Cui, Jianling
Chen, Chunyan
author_facet Wan, Xiaoqing
Liao, Jian
Lai, Hongting
Zhang, Shilong
Cui, Jianling
Chen, Chunyan
author_sort Wan, Xiaoqing
collection PubMed
description Diabetic nephropathy (DN) is one of the most common and intractable microvascular complications of diabetes worldwide, serving as the main cause of terminal renal disease. Due to the lack of early specific symptoms and diagnostic markers, DN severely threatens the sufferer’s life. MicroRNA-192 (miR-192) was early identified in human renal cortical tissue and stored and excreted in urine as microvesicles. MiR-192 was found to be involved in the development of DN. For the first time, the present review summarized all the current evidence on the topic of the roles of miR-192 in DN. Finally, 28 studies (ten clinical trials and eighteen experimental studies) were eligible for thorough reviewing. Most of the clinical trials (7/10, 70%) indicated miR-192 might be a protective factor for DN development and progression, while the majority of experimental studies (14/18, 78%) suggested miR-192 might be a pathogenic factor for DN. Mechanistically, miR-192 interacts with various direct targeted proteins (i.e., ZEB1, ZEB2, SIP1, GLP1R, and Egr1) and signaling cascades (i.e., SMAD/TGF-β and PTEN/PI3K/AKT), together contribute to the pathogenesis of DN through epithelial-to-mesenchymal transition (EMT), extracellular matrix deposition, and fibrosis formation. The current review highlights the dual role of miR-192 in the development of DN. Low serum miR-192 expression could be applied for the early prediction of DN (the early stage of DN), while the high miR-192 level in renal tissues and urine may imply the progression of DN (the late stage of DN). Further investigations are still warranted to illustrate this inconsistent phenomenon, which may facilitate promoting the therapeutic applications of miR-192 in predicting and treating DN.
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spelling pubmed-103095602023-06-30 Roles of microRNA-192 in diabetic nephropathy: the clinical applications and mechanisms of action Wan, Xiaoqing Liao, Jian Lai, Hongting Zhang, Shilong Cui, Jianling Chen, Chunyan Front Endocrinol (Lausanne) Endocrinology Diabetic nephropathy (DN) is one of the most common and intractable microvascular complications of diabetes worldwide, serving as the main cause of terminal renal disease. Due to the lack of early specific symptoms and diagnostic markers, DN severely threatens the sufferer’s life. MicroRNA-192 (miR-192) was early identified in human renal cortical tissue and stored and excreted in urine as microvesicles. MiR-192 was found to be involved in the development of DN. For the first time, the present review summarized all the current evidence on the topic of the roles of miR-192 in DN. Finally, 28 studies (ten clinical trials and eighteen experimental studies) were eligible for thorough reviewing. Most of the clinical trials (7/10, 70%) indicated miR-192 might be a protective factor for DN development and progression, while the majority of experimental studies (14/18, 78%) suggested miR-192 might be a pathogenic factor for DN. Mechanistically, miR-192 interacts with various direct targeted proteins (i.e., ZEB1, ZEB2, SIP1, GLP1R, and Egr1) and signaling cascades (i.e., SMAD/TGF-β and PTEN/PI3K/AKT), together contribute to the pathogenesis of DN through epithelial-to-mesenchymal transition (EMT), extracellular matrix deposition, and fibrosis formation. The current review highlights the dual role of miR-192 in the development of DN. Low serum miR-192 expression could be applied for the early prediction of DN (the early stage of DN), while the high miR-192 level in renal tissues and urine may imply the progression of DN (the late stage of DN). Further investigations are still warranted to illustrate this inconsistent phenomenon, which may facilitate promoting the therapeutic applications of miR-192 in predicting and treating DN. Frontiers Media S.A. 2023-06-15 /pmc/articles/PMC10309560/ /pubmed/37396169 http://dx.doi.org/10.3389/fendo.2023.1179161 Text en Copyright © 2023 Wan, Liao, Lai, Zhang, Cui and Chen https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Wan, Xiaoqing
Liao, Jian
Lai, Hongting
Zhang, Shilong
Cui, Jianling
Chen, Chunyan
Roles of microRNA-192 in diabetic nephropathy: the clinical applications and mechanisms of action
title Roles of microRNA-192 in diabetic nephropathy: the clinical applications and mechanisms of action
title_full Roles of microRNA-192 in diabetic nephropathy: the clinical applications and mechanisms of action
title_fullStr Roles of microRNA-192 in diabetic nephropathy: the clinical applications and mechanisms of action
title_full_unstemmed Roles of microRNA-192 in diabetic nephropathy: the clinical applications and mechanisms of action
title_short Roles of microRNA-192 in diabetic nephropathy: the clinical applications and mechanisms of action
title_sort roles of microrna-192 in diabetic nephropathy: the clinical applications and mechanisms of action
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10309560/
https://www.ncbi.nlm.nih.gov/pubmed/37396169
http://dx.doi.org/10.3389/fendo.2023.1179161
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