Comprehensive Review on the Clinical Impact of Next-Generation Sequencing Tests for the Management of Advanced Cancer

This review summarizes the published evidence on the clinical impact of using next-generation sequencing (NGS) tests to guide management of patients with cancer in the United States. METHODS: We performed a comprehensive literature review to identify recent English language publications that present...

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Autores principales: Gibbs, Sarah N., Peneva, Desi, Cuyun Carter, Gebra, Palomares, Melanie R., Thakkar, Snehal, Hall, David W., Dalglish, Hannah, Campos, Cynthia, Yermilov, Irina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2023
Materias:
REVIEW ARTICLES
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10309568/
https://www.ncbi.nlm.nih.gov/pubmed/37285561
http://dx.doi.org/10.1200/PO.22.00715
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author Gibbs, Sarah N.
Peneva, Desi
Cuyun Carter, Gebra
Palomares, Melanie R.
Thakkar, Snehal
Hall, David W.
Dalglish, Hannah
Campos, Cynthia
Yermilov, Irina
author_facet Gibbs, Sarah N.
Peneva, Desi
Cuyun Carter, Gebra
Palomares, Melanie R.
Thakkar, Snehal
Hall, David W.
Dalglish, Hannah
Campos, Cynthia
Yermilov, Irina
author_sort Gibbs, Sarah N.
collection PubMed
description This review summarizes the published evidence on the clinical impact of using next-generation sequencing (NGS) tests to guide management of patients with cancer in the United States. METHODS: We performed a comprehensive literature review to identify recent English language publications that presented progression-free survival (PFS) and overall survival (OS) of patients with advanced cancer receiving NGS testing. RESULTS: Among 6,475 publications identified, 31 evaluated PFS and OS among subgroups of patients who received NGS-informed cancer management. PFS and OS were significantly longer among patients who were matched to targeted treatment in 11 and 16 publications across tumor types, respectively. CONCLUSION: Our review indicates that NGS-informed treatment can have an impact on survival across tumor types.
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spelling pubmed-103095682023-06-30 Comprehensive Review on the Clinical Impact of Next-Generation Sequencing Tests for the Management of Advanced Cancer Gibbs, Sarah N. Peneva, Desi Cuyun Carter, Gebra Palomares, Melanie R. Thakkar, Snehal Hall, David W. Dalglish, Hannah Campos, Cynthia Yermilov, Irina JCO Precis Oncol REVIEW ARTICLES This review summarizes the published evidence on the clinical impact of using next-generation sequencing (NGS) tests to guide management of patients with cancer in the United States. METHODS: We performed a comprehensive literature review to identify recent English language publications that presented progression-free survival (PFS) and overall survival (OS) of patients with advanced cancer receiving NGS testing. RESULTS: Among 6,475 publications identified, 31 evaluated PFS and OS among subgroups of patients who received NGS-informed cancer management. PFS and OS were significantly longer among patients who were matched to targeted treatment in 11 and 16 publications across tumor types, respectively. CONCLUSION: Our review indicates that NGS-informed treatment can have an impact on survival across tumor types. Wolters Kluwer Health 2023-06-07 /pmc/articles/PMC10309568/ /pubmed/37285561 http://dx.doi.org/10.1200/PO.22.00715 Text en © 2023 by American Society of Clinical Oncology https://creativecommons.org/licenses/by-nc-nd/4.0/Creative Commons Attribution Non-Commercial No Derivatives 4.0 License: http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle REVIEW ARTICLES
Gibbs, Sarah N.
Peneva, Desi
Cuyun Carter, Gebra
Palomares, Melanie R.
Thakkar, Snehal
Hall, David W.
Dalglish, Hannah
Campos, Cynthia
Yermilov, Irina
Comprehensive Review on the Clinical Impact of Next-Generation Sequencing Tests for the Management of Advanced Cancer
title Comprehensive Review on the Clinical Impact of Next-Generation Sequencing Tests for the Management of Advanced Cancer
title_full Comprehensive Review on the Clinical Impact of Next-Generation Sequencing Tests for the Management of Advanced Cancer
title_fullStr Comprehensive Review on the Clinical Impact of Next-Generation Sequencing Tests for the Management of Advanced Cancer
title_full_unstemmed Comprehensive Review on the Clinical Impact of Next-Generation Sequencing Tests for the Management of Advanced Cancer
title_short Comprehensive Review on the Clinical Impact of Next-Generation Sequencing Tests for the Management of Advanced Cancer
title_sort comprehensive review on the clinical impact of next-generation sequencing tests for the management of advanced cancer
topic REVIEW ARTICLES
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10309568/
https://www.ncbi.nlm.nih.gov/pubmed/37285561
http://dx.doi.org/10.1200/PO.22.00715
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