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Clonal Hematopoiesis: Updates and Implications at the Solid Tumor-Immune Interface
Recent larger-scale studies of patients with cancer and longitudinal population cohorts have revealed how age-related expansions of mutant hematopoietic cells (clonal hematopoiesis [CH]) have differential associations with incident and prevalent cancers and their outcomes. Increasing recognition and...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10309572/ https://www.ncbi.nlm.nih.gov/pubmed/37343201 http://dx.doi.org/10.1200/PO.23.00132 |
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author | Buttigieg, Marco M. Rauh, Michael J. |
author_facet | Buttigieg, Marco M. Rauh, Michael J. |
author_sort | Buttigieg, Marco M. |
collection | PubMed |
description | Recent larger-scale studies of patients with cancer and longitudinal population cohorts have revealed how age-related expansions of mutant hematopoietic cells (clonal hematopoiesis [CH]) have differential associations with incident and prevalent cancers and their outcomes. Increasing recognition and deeper understanding of genetic subtypes of CH are yielding insights into the tumor-immune interface that may help to explain the heterogeneous impact of CH on tumorigenesis and treatment. Herein, we update the expanding influence of CH in precision oncology and propose important research and clinical questions to address to effectively manage and harness CH in oncology patients. |
format | Online Article Text |
id | pubmed-10309572 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-103095722023-06-30 Clonal Hematopoiesis: Updates and Implications at the Solid Tumor-Immune Interface Buttigieg, Marco M. Rauh, Michael J. JCO Precis Oncol REVIEW ARTICLES Recent larger-scale studies of patients with cancer and longitudinal population cohorts have revealed how age-related expansions of mutant hematopoietic cells (clonal hematopoiesis [CH]) have differential associations with incident and prevalent cancers and their outcomes. Increasing recognition and deeper understanding of genetic subtypes of CH are yielding insights into the tumor-immune interface that may help to explain the heterogeneous impact of CH on tumorigenesis and treatment. Herein, we update the expanding influence of CH in precision oncology and propose important research and clinical questions to address to effectively manage and harness CH in oncology patients. Wolters Kluwer Health 2023-06-21 /pmc/articles/PMC10309572/ /pubmed/37343201 http://dx.doi.org/10.1200/PO.23.00132 Text en © 2023 by American Society of Clinical Oncology https://creativecommons.org/licenses/by/4.0/Licensed under the Creative Commons Attribution 4.0 License: https://creativecommons.org/licenses/by/4.0/ |
spellingShingle | REVIEW ARTICLES Buttigieg, Marco M. Rauh, Michael J. Clonal Hematopoiesis: Updates and Implications at the Solid Tumor-Immune Interface |
title | Clonal Hematopoiesis: Updates and Implications at the Solid Tumor-Immune Interface |
title_full | Clonal Hematopoiesis: Updates and Implications at the Solid Tumor-Immune Interface |
title_fullStr | Clonal Hematopoiesis: Updates and Implications at the Solid Tumor-Immune Interface |
title_full_unstemmed | Clonal Hematopoiesis: Updates and Implications at the Solid Tumor-Immune Interface |
title_short | Clonal Hematopoiesis: Updates and Implications at the Solid Tumor-Immune Interface |
title_sort | clonal hematopoiesis: updates and implications at the solid tumor-immune interface |
topic | REVIEW ARTICLES |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10309572/ https://www.ncbi.nlm.nih.gov/pubmed/37343201 http://dx.doi.org/10.1200/PO.23.00132 |
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