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Clonal Hematopoiesis: Updates and Implications at the Solid Tumor-Immune Interface

Recent larger-scale studies of patients with cancer and longitudinal population cohorts have revealed how age-related expansions of mutant hematopoietic cells (clonal hematopoiesis [CH]) have differential associations with incident and prevalent cancers and their outcomes. Increasing recognition and...

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Detalles Bibliográficos
Autores principales: Buttigieg, Marco M., Rauh, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10309572/
https://www.ncbi.nlm.nih.gov/pubmed/37343201
http://dx.doi.org/10.1200/PO.23.00132
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author Buttigieg, Marco M.
Rauh, Michael J.
author_facet Buttigieg, Marco M.
Rauh, Michael J.
author_sort Buttigieg, Marco M.
collection PubMed
description Recent larger-scale studies of patients with cancer and longitudinal population cohorts have revealed how age-related expansions of mutant hematopoietic cells (clonal hematopoiesis [CH]) have differential associations with incident and prevalent cancers and their outcomes. Increasing recognition and deeper understanding of genetic subtypes of CH are yielding insights into the tumor-immune interface that may help to explain the heterogeneous impact of CH on tumorigenesis and treatment. Herein, we update the expanding influence of CH in precision oncology and propose important research and clinical questions to address to effectively manage and harness CH in oncology patients.
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spelling pubmed-103095722023-06-30 Clonal Hematopoiesis: Updates and Implications at the Solid Tumor-Immune Interface Buttigieg, Marco M. Rauh, Michael J. JCO Precis Oncol REVIEW ARTICLES Recent larger-scale studies of patients with cancer and longitudinal population cohorts have revealed how age-related expansions of mutant hematopoietic cells (clonal hematopoiesis [CH]) have differential associations with incident and prevalent cancers and their outcomes. Increasing recognition and deeper understanding of genetic subtypes of CH are yielding insights into the tumor-immune interface that may help to explain the heterogeneous impact of CH on tumorigenesis and treatment. Herein, we update the expanding influence of CH in precision oncology and propose important research and clinical questions to address to effectively manage and harness CH in oncology patients. Wolters Kluwer Health 2023-06-21 /pmc/articles/PMC10309572/ /pubmed/37343201 http://dx.doi.org/10.1200/PO.23.00132 Text en © 2023 by American Society of Clinical Oncology https://creativecommons.org/licenses/by/4.0/Licensed under the Creative Commons Attribution 4.0 License: https://creativecommons.org/licenses/by/4.0/
spellingShingle REVIEW ARTICLES
Buttigieg, Marco M.
Rauh, Michael J.
Clonal Hematopoiesis: Updates and Implications at the Solid Tumor-Immune Interface
title Clonal Hematopoiesis: Updates and Implications at the Solid Tumor-Immune Interface
title_full Clonal Hematopoiesis: Updates and Implications at the Solid Tumor-Immune Interface
title_fullStr Clonal Hematopoiesis: Updates and Implications at the Solid Tumor-Immune Interface
title_full_unstemmed Clonal Hematopoiesis: Updates and Implications at the Solid Tumor-Immune Interface
title_short Clonal Hematopoiesis: Updates and Implications at the Solid Tumor-Immune Interface
title_sort clonal hematopoiesis: updates and implications at the solid tumor-immune interface
topic REVIEW ARTICLES
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10309572/
https://www.ncbi.nlm.nih.gov/pubmed/37343201
http://dx.doi.org/10.1200/PO.23.00132
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