Antigen pressure from two founder viruses induces multiple insertions at a single antibody position to generate broadly neutralizing HIV antibodies

Vaccination strategies aimed at maturing broadly neutralizing antibodies (bnAbs) from naïve precursors are hindered by unusual features that characterize these Abs, including insertions and deletions (indels). Longitudinal studies of natural HIV infection cases shed light on the complex processes un...

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Detalles Bibliográficos
Autores principales: Joyce, Collin, Murrell, Sasha, Murrell, Ben, Omorodion, Oluwarotimi, Ver, Lorena S., Carrico, Nancy, Bastidas, Raiza, Nedellec, Rebecca, Bick, Michael, Woehl, Jordan, Zhao, Fangzhu, Burns, Alison, Barman, Shawn, Appel, Michael, Ramos, Alejandra, Wickramasinghe, Lalinda, Eren, Kemal, Vollbrecht, Thomas, Smith, Davey M., Kosakovsky Pond, Sergei L., McBride, Ryan, Worth, Charli, Batista, Facundo, Sok, Devin, Poignard, Pascal, Briney, Bryan, Wilson, Ian A., Landais, Elise, Burton, Dennis R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10309625/
https://www.ncbi.nlm.nih.gov/pubmed/37384622
http://dx.doi.org/10.1371/journal.ppat.1011416

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