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Impact of overweight and obesity on disease activity and remission in systemic lupus erythematosus: A systematic review and meta-analysis protocol

BACKGROUND: Systemic lupus erythematosus (SLE) is an autoimmune and inflammatory disease that requires treatment with hydroxychloroquine and glucocorticoids. Glucocorticoids are responsible for adverse effects such as increased weight, which can modify the severity and chronicity of autoimmune patho...

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Autores principales: de Medeiros, Marília Cristina Santos, de Souza, Karla Simone Costa, Galdino, Ony Araújo, Cobucci, Ricardo Ney, de Rezende, Adriana Augusto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10309980/
https://www.ncbi.nlm.nih.gov/pubmed/37384711
http://dx.doi.org/10.1371/journal.pone.0287753
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author de Medeiros, Marília Cristina Santos
de Souza, Karla Simone Costa
Galdino, Ony Araújo
Cobucci, Ricardo Ney
de Rezende, Adriana Augusto
author_facet de Medeiros, Marília Cristina Santos
de Souza, Karla Simone Costa
Galdino, Ony Araújo
Cobucci, Ricardo Ney
de Rezende, Adriana Augusto
author_sort de Medeiros, Marília Cristina Santos
collection PubMed
description BACKGROUND: Systemic lupus erythematosus (SLE) is an autoimmune and inflammatory disease that requires treatment with hydroxychloroquine and glucocorticoids. Glucocorticoids are responsible for adverse effects such as increased weight, which can modify the severity and chronicity of autoimmune pathologies. AIM: To summarize scientific evidence regarding the impact of overweight and obesity on disease activity and remission in SLE. METHODS: The protocol was developed according to the Preferred Reporting Items for Systematic Review and Meta-analysis Protocol (PRISMA-P) and published in the International Prospective Register of Systematic Reviews database (PROSPERO—CRD42021268217). PubMed, Scopus, Embase, and Google Scholar will be searched for observational studies including adult patients with SLE who were overweight and obese or not, that included disease activity or remission as outcomes. The search is planned for May 2023. Three independent authors will select the eligible articles and extract their data. Subsequently, three authors will independently extract data from each included study using an extraction form created by the researchers. Methodological quality analyses will be performed using the modified Newcastle-Ottawa scale. The results will be presented as a narrative synthesis according to the synthesis without a meta-analysis reporting guideline (SWiM). Meta-analysis will be conducted where appropriate using random-effects models. EXPECTED RESULTS: This review will identify the impact of overweight and obesity on the clinical features of SLE, helping clinicians manage disease activity and remission, both important to optimize disease outcomes and patient quality of life.
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spelling pubmed-103099802023-06-30 Impact of overweight and obesity on disease activity and remission in systemic lupus erythematosus: A systematic review and meta-analysis protocol de Medeiros, Marília Cristina Santos de Souza, Karla Simone Costa Galdino, Ony Araújo Cobucci, Ricardo Ney de Rezende, Adriana Augusto PLoS One Study Protocol BACKGROUND: Systemic lupus erythematosus (SLE) is an autoimmune and inflammatory disease that requires treatment with hydroxychloroquine and glucocorticoids. Glucocorticoids are responsible for adverse effects such as increased weight, which can modify the severity and chronicity of autoimmune pathologies. AIM: To summarize scientific evidence regarding the impact of overweight and obesity on disease activity and remission in SLE. METHODS: The protocol was developed according to the Preferred Reporting Items for Systematic Review and Meta-analysis Protocol (PRISMA-P) and published in the International Prospective Register of Systematic Reviews database (PROSPERO—CRD42021268217). PubMed, Scopus, Embase, and Google Scholar will be searched for observational studies including adult patients with SLE who were overweight and obese or not, that included disease activity or remission as outcomes. The search is planned for May 2023. Three independent authors will select the eligible articles and extract their data. Subsequently, three authors will independently extract data from each included study using an extraction form created by the researchers. Methodological quality analyses will be performed using the modified Newcastle-Ottawa scale. The results will be presented as a narrative synthesis according to the synthesis without a meta-analysis reporting guideline (SWiM). Meta-analysis will be conducted where appropriate using random-effects models. EXPECTED RESULTS: This review will identify the impact of overweight and obesity on the clinical features of SLE, helping clinicians manage disease activity and remission, both important to optimize disease outcomes and patient quality of life. Public Library of Science 2023-06-29 /pmc/articles/PMC10309980/ /pubmed/37384711 http://dx.doi.org/10.1371/journal.pone.0287753 Text en © 2023 Medeiros et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Study Protocol
de Medeiros, Marília Cristina Santos
de Souza, Karla Simone Costa
Galdino, Ony Araújo
Cobucci, Ricardo Ney
de Rezende, Adriana Augusto
Impact of overweight and obesity on disease activity and remission in systemic lupus erythematosus: A systematic review and meta-analysis protocol
title Impact of overweight and obesity on disease activity and remission in systemic lupus erythematosus: A systematic review and meta-analysis protocol
title_full Impact of overweight and obesity on disease activity and remission in systemic lupus erythematosus: A systematic review and meta-analysis protocol
title_fullStr Impact of overweight and obesity on disease activity and remission in systemic lupus erythematosus: A systematic review and meta-analysis protocol
title_full_unstemmed Impact of overweight and obesity on disease activity and remission in systemic lupus erythematosus: A systematic review and meta-analysis protocol
title_short Impact of overweight and obesity on disease activity and remission in systemic lupus erythematosus: A systematic review and meta-analysis protocol
title_sort impact of overweight and obesity on disease activity and remission in systemic lupus erythematosus: a systematic review and meta-analysis protocol
topic Study Protocol
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10309980/
https://www.ncbi.nlm.nih.gov/pubmed/37384711
http://dx.doi.org/10.1371/journal.pone.0287753
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