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HTLV-1 Hbz protein, but not hbz mRNA secondary structure, is critical for viral persistence and disease development

Human T-cell leukemia virus type 1 (HTLV-1) is the etiologic cause of adult T-cell leukemia/lymphoma (ATL) and encodes a viral oncoprotein (Hbz) that is consistently expressed in asymptomatic carriers and ATL patients, suggesting its importance in the development and maintenance of HTLV-1 leukemic c...

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Detalles Bibliográficos
Autores principales: Maksimova, Victoria, Wilkie, Tasha, Smith, Susan, Phelps, Cameron, Melvin, Corrine, Yu, Lianbo, Niewiesk, Stefan, Green, Patrick L., Panfil, Amanda R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10309998/
https://www.ncbi.nlm.nih.gov/pubmed/37327244
http://dx.doi.org/10.1371/journal.ppat.1011459