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Exploring interhemispheric connectivity using the directional tract density patterns of the corpus callosum

The corpus callosum (CC) is one of the most important interhemispheric white matter tracts that connects interrelated regions of the cerebral cortex. Its disruption has been investigated in previous studies and has been found to play an important role in several neurodegenerative disorders. Currentl...

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Autores principales: Demir, Ali, Rosas, H. Diana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10310067/
https://www.ncbi.nlm.nih.gov/pubmed/37388455
http://dx.doi.org/10.1016/j.ynirp.2023.100174
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author Demir, Ali
Rosas, H. Diana
author_facet Demir, Ali
Rosas, H. Diana
author_sort Demir, Ali
collection PubMed
description The corpus callosum (CC) is one of the most important interhemispheric white matter tracts that connects interrelated regions of the cerebral cortex. Its disruption has been investigated in previous studies and has been found to play an important role in several neurodegenerative disorders. Currently available methods to assess the interhemispheric connectivity of the CC have several limitations: i) they require the a priori identification of specific cortical regions as targets or seeds, ii) they are limited by the characterization of only small components of the structure, primarily voxels that constitute the mid-sagittal slice, and iii) they use global measures of microstructural integrity, which provide only limited characterization. In order to address some of these limitations, we developed a novel method that enables the characterization of white matter tracts covering the structure of CC, from the mid-sagittal plane to corresponding regions of cortex, using directional tract density patterns (dTDPs). We demonstrate that different regions of CC have distinctive dTDPs that reflect a unique regional topology. We conducted a pilot study using this approach to evaluate two different datasets collected from healthy subjects, and we demonstrate that this method is reliable, reproducible, and independent of diffusion acquisition parameters, suggesting its potential applicability to clinical applications.
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spelling pubmed-103100672023-06-29 Exploring interhemispheric connectivity using the directional tract density patterns of the corpus callosum Demir, Ali Rosas, H. Diana Neuroimage Rep Article The corpus callosum (CC) is one of the most important interhemispheric white matter tracts that connects interrelated regions of the cerebral cortex. Its disruption has been investigated in previous studies and has been found to play an important role in several neurodegenerative disorders. Currently available methods to assess the interhemispheric connectivity of the CC have several limitations: i) they require the a priori identification of specific cortical regions as targets or seeds, ii) they are limited by the characterization of only small components of the structure, primarily voxels that constitute the mid-sagittal slice, and iii) they use global measures of microstructural integrity, which provide only limited characterization. In order to address some of these limitations, we developed a novel method that enables the characterization of white matter tracts covering the structure of CC, from the mid-sagittal plane to corresponding regions of cortex, using directional tract density patterns (dTDPs). We demonstrate that different regions of CC have distinctive dTDPs that reflect a unique regional topology. We conducted a pilot study using this approach to evaluate two different datasets collected from healthy subjects, and we demonstrate that this method is reliable, reproducible, and independent of diffusion acquisition parameters, suggesting its potential applicability to clinical applications. 2023-06 2023-06-03 /pmc/articles/PMC10310067/ /pubmed/37388455 http://dx.doi.org/10.1016/j.ynirp.2023.100174 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ).
spellingShingle Article
Demir, Ali
Rosas, H. Diana
Exploring interhemispheric connectivity using the directional tract density patterns of the corpus callosum
title Exploring interhemispheric connectivity using the directional tract density patterns of the corpus callosum
title_full Exploring interhemispheric connectivity using the directional tract density patterns of the corpus callosum
title_fullStr Exploring interhemispheric connectivity using the directional tract density patterns of the corpus callosum
title_full_unstemmed Exploring interhemispheric connectivity using the directional tract density patterns of the corpus callosum
title_short Exploring interhemispheric connectivity using the directional tract density patterns of the corpus callosum
title_sort exploring interhemispheric connectivity using the directional tract density patterns of the corpus callosum
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10310067/
https://www.ncbi.nlm.nih.gov/pubmed/37388455
http://dx.doi.org/10.1016/j.ynirp.2023.100174
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