Advanced breast cancer metastasized in the brain: treatment standards and innovations

Breast cancer continues to be a difficult disease to treat due to high rates of metastasis. Metastasis to the brain presents a unique and often overlooked challenge. In this focused review, we discuss the epidemiology of breast cancer and which types frequently metastasize to the brain. Novel treatm...

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Detalles Bibliográficos
Autores principales: Klaas, Elizabeth, Sung, Eric, Azizi, Esaan, Martinez, Melanie, Barpujari, Arnav, Roberts, Jeffery, Lucke-Wold, Brandon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10310293/
https://www.ncbi.nlm.nih.gov/pubmed/37388704
http://dx.doi.org/10.20517/2394-4722.2022.125
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author Klaas, Elizabeth
Sung, Eric
Azizi, Esaan
Martinez, Melanie
Barpujari, Arnav
Roberts, Jeffery
Lucke-Wold, Brandon
author_facet Klaas, Elizabeth
Sung, Eric
Azizi, Esaan
Martinez, Melanie
Barpujari, Arnav
Roberts, Jeffery
Lucke-Wold, Brandon
author_sort Klaas, Elizabeth
collection PubMed
description Breast cancer continues to be a difficult disease to treat due to high rates of metastasis. Metastasis to the brain presents a unique and often overlooked challenge. In this focused review, we discuss the epidemiology of breast cancer and which types frequently metastasize to the brain. Novel treatment approaches are highlighted with supporting scientific evidence. The role of the blood-brain barrier and how it may become altered with metastasis is addressed. We then highlight new innovations for Her2-positive and triple-negative breast cancer. Finally, recent directions for luminal breast cancer are discussed. This review serves to enhance understanding of pathophysiology, spark continued innovation, and provide a user-friendly resource through tables and easy-to-process figures.
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spelling pubmed-103102932023-06-29 Advanced breast cancer metastasized in the brain: treatment standards and innovations Klaas, Elizabeth Sung, Eric Azizi, Esaan Martinez, Melanie Barpujari, Arnav Roberts, Jeffery Lucke-Wold, Brandon J Cancer Metastasis Treat Article Breast cancer continues to be a difficult disease to treat due to high rates of metastasis. Metastasis to the brain presents a unique and often overlooked challenge. In this focused review, we discuss the epidemiology of breast cancer and which types frequently metastasize to the brain. Novel treatment approaches are highlighted with supporting scientific evidence. The role of the blood-brain barrier and how it may become altered with metastasis is addressed. We then highlight new innovations for Her2-positive and triple-negative breast cancer. Finally, recent directions for luminal breast cancer are discussed. This review serves to enhance understanding of pathophysiology, spark continued innovation, and provide a user-friendly resource through tables and easy-to-process figures. 2023 2023-06-14 /pmc/articles/PMC10310293/ /pubmed/37388704 http://dx.doi.org/10.20517/2394-4722.2022.125 Text en https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Article
Klaas, Elizabeth
Sung, Eric
Azizi, Esaan
Martinez, Melanie
Barpujari, Arnav
Roberts, Jeffery
Lucke-Wold, Brandon
Advanced breast cancer metastasized in the brain: treatment standards and innovations
title Advanced breast cancer metastasized in the brain: treatment standards and innovations
title_full Advanced breast cancer metastasized in the brain: treatment standards and innovations
title_fullStr Advanced breast cancer metastasized in the brain: treatment standards and innovations
title_full_unstemmed Advanced breast cancer metastasized in the brain: treatment standards and innovations
title_short Advanced breast cancer metastasized in the brain: treatment standards and innovations
title_sort advanced breast cancer metastasized in the brain: treatment standards and innovations
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10310293/
https://www.ncbi.nlm.nih.gov/pubmed/37388704
http://dx.doi.org/10.20517/2394-4722.2022.125
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