Nationwide Outbreak of Candida auris Infections Driven by COVID-19 Hospitalizations, Israel, 2021–2022

We report an outbreak of Candida auris across multiple healthcare facilities in Israel. For the period of May 2014–May 2022, a total of 209 patients with C. auris infection or colonization were identified. The C. auris incidence rate increased 30-fold in 2021 (p = 0.00015), corresponding in time wit...

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Detalles Bibliográficos
Autores principales: Biran, Roni, Cohen, Regev, Finn, Talya, Brosh-Nissimov, Tal, Rahav, Galia, Yahav, Dafna, Amit, Sharon, Shachor-Meyouhas, Yael, Atamna, Alaa, Bishara, Jihad, Ashkenazi-Hoffnung, Liat, Ben Zvi, Haim, Hershman-Sarafov, Mirit, Maayan, Shlomo, Maor, Yasmin, Schwartz, Orna, Zimhony, Oren, Lellouche, Jonathan, Elbaz, Meital, Burdelova, Ela, Mizrahi, Naama, Novikov, Anna, Henig, Oryan, Ben-Ami, Ronen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2023
Materias:
Synopsis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10310389/
https://www.ncbi.nlm.nih.gov/pubmed/37347492
http://dx.doi.org/10.3201/eid2907.221888
Descripción
Sumario:We report an outbreak of Candida auris across multiple healthcare facilities in Israel. For the period of May 2014–May 2022, a total of 209 patients with C. auris infection or colonization were identified. The C. auris incidence rate increased 30-fold in 2021 (p = 0.00015), corresponding in time with surges of COVID-19–related hospitalization. Multilocus sequence typing revealed hospital-level outbreaks with distinct clones. A clade III clone, imported into Israel in 2016, accounted for 48.8% of typed isolates after January 2021 and was more frequently resistant to fluconazole (100% vs. 63%; p = 0.00017) and voriconazole (74% vs. 5.2%; p<0.0001) than were non–clade III isolates. A total of 23% of patients had COVID-19, and 78% received mechanical ventilation. At the hospital level, outbreaks initially involved mechanically ventilated patients in specialized COVID-19 units and then spread sequentially to ventilated non–COVID-19 patients and nonventilated patients.

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