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Early hyperlipidemia triggers metabolomic reprogramming with increased SAH, increased acetyl-CoA-cholesterol synthesis, and decreased glycolysis

To identify metabolomic reprogramming in early hyperlipidemia, unbiased metabolome was screened in four tissues from ApoE(−/−) mice fed with high fat diet (HFD) for 3 weeks. 30, 122, 67, and 97 metabolites in the aorta, heart, liver, and plasma, respectively, were upregulated. 9 upregulated metaboli...

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Detalles Bibliográficos
Autores principales:	Xu, Keman, Saaoud, Fatma, Shao, Ying, Lu, Yifan, Wu, Sheng, Zhao, Huaqing, Chen, Kaifu, Vazquez-Padron, Roberto, Jiang, Xiaohua, Wang, Hong, Yang, Xiaofeng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10310484/ https://www.ncbi.nlm.nih.gov/pubmed/37364513 http://dx.doi.org/10.1016/j.redox.2023.102771

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