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Sickle cell leg ulcer successfully managed by hyperbaric oxygen: a case report
Sickle cell leg ulcers (SCLUs) are usually chronic, painful, and devastating complications of sickle cell disease. Skin vaso-occlusion with compromised blood flow, chronic inflammation, and endothelial dysfunction is thought to be the underlying mechanism. It is usually slow to heal, and it may beco...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10310543/ https://www.ncbi.nlm.nih.gov/pubmed/37396892 http://dx.doi.org/10.3389/fmed.2023.1171971 |
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author | Alshurafa, Awni Alkhatib, Mohammed Abu-Tineh, Mohammad Yassin, Mohamed A. |
author_facet | Alshurafa, Awni Alkhatib, Mohammed Abu-Tineh, Mohammad Yassin, Mohamed A. |
author_sort | Alshurafa, Awni |
collection | PubMed |
description | Sickle cell leg ulcers (SCLUs) are usually chronic, painful, and devastating complications of sickle cell disease. Skin vaso-occlusion with compromised blood flow, chronic inflammation, and endothelial dysfunction is thought to be the underlying mechanism. It is usually slow to heal, and it may become chronic and superinfected. The management of SCLUs is usually challenging and requires a multidisciplinary team. Multiple systemic and local therapies have been tried in SCLU treatment. However, the outcome is variable: currently, there are no official recommendations for the best effective treatment. Herein, we report a 34-year-old male patient with non-transfusion-dependent sickle cell disease who was suffering from a chronic left ankle ulcer and was successfully managed with hyperbaric oxygen therapy, resulting in a complete resolution of this devastating complication. |
format | Online Article Text |
id | pubmed-10310543 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-103105432023-07-01 Sickle cell leg ulcer successfully managed by hyperbaric oxygen: a case report Alshurafa, Awni Alkhatib, Mohammed Abu-Tineh, Mohammad Yassin, Mohamed A. Front Med (Lausanne) Medicine Sickle cell leg ulcers (SCLUs) are usually chronic, painful, and devastating complications of sickle cell disease. Skin vaso-occlusion with compromised blood flow, chronic inflammation, and endothelial dysfunction is thought to be the underlying mechanism. It is usually slow to heal, and it may become chronic and superinfected. The management of SCLUs is usually challenging and requires a multidisciplinary team. Multiple systemic and local therapies have been tried in SCLU treatment. However, the outcome is variable: currently, there are no official recommendations for the best effective treatment. Herein, we report a 34-year-old male patient with non-transfusion-dependent sickle cell disease who was suffering from a chronic left ankle ulcer and was successfully managed with hyperbaric oxygen therapy, resulting in a complete resolution of this devastating complication. Frontiers Media S.A. 2023-06-15 /pmc/articles/PMC10310543/ /pubmed/37396892 http://dx.doi.org/10.3389/fmed.2023.1171971 Text en Copyright © 2023 Alshurafa, Alkhatib, Abu-Tineh and Yassin. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Medicine Alshurafa, Awni Alkhatib, Mohammed Abu-Tineh, Mohammad Yassin, Mohamed A. Sickle cell leg ulcer successfully managed by hyperbaric oxygen: a case report |
title | Sickle cell leg ulcer successfully managed by hyperbaric oxygen: a case report |
title_full | Sickle cell leg ulcer successfully managed by hyperbaric oxygen: a case report |
title_fullStr | Sickle cell leg ulcer successfully managed by hyperbaric oxygen: a case report |
title_full_unstemmed | Sickle cell leg ulcer successfully managed by hyperbaric oxygen: a case report |
title_short | Sickle cell leg ulcer successfully managed by hyperbaric oxygen: a case report |
title_sort | sickle cell leg ulcer successfully managed by hyperbaric oxygen: a case report |
topic | Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10310543/ https://www.ncbi.nlm.nih.gov/pubmed/37396892 http://dx.doi.org/10.3389/fmed.2023.1171971 |
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