Quantification of olanzapine and its three metabolites by liquid chromatography–tandem mass spectrometry in human body fluids obtained from four deceased, and confirmation of the reduction from olanzapine N-oxide to olanzapine in whole blood in vitro

PURPOSE: Quantification of olanzapine (OLZ) and its metabolites such as N-desmethylolanzapine (DM-O), 2-hydroxymethylolanzapine (2H-O) and olanzapine N-oxide (NO-O) in five kinds of human body fluids including whole blood by liquid chromatography (LC)–tandem mass spectrometry (MS/MS) has been presen...

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Detalles Bibliográficos
Autores principales: Nozawa, Hideki, Minakata, Kayoko, Hasegawa, Koutaro, Yamagishi, Itaru, Miyoshi, Naotomo, Suzuki, Masako, Kitamoto, Takuya, Kondo, Minako, Watanabe, Kanako, Suzuki, Osamu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10310574/
https://www.ncbi.nlm.nih.gov/pubmed/36997675
http://dx.doi.org/10.1007/s11419-023-00662-0

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