High glucose induces tau hyperphosphorylation in hippocampal neurons via inhibition of ALKBH5-mediated Dgkh m(6)A demethylation: a potential mechanism for diabetic cognitive dysfunction

Tau hyperphosphorylation in hippocampal neurons has an important pathogenetic role in the development of diabetic cognitive dysfunction. N(6)-methyladenosine (m(6)A) methylation is the most common modification of eukaryotic mRNA and is involved in regulating diverse biological processes. However, th...

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Detalles Bibliográficos
Autores principales: Qu, Minli, Zuo, Linhui, Zhang, Mengru, Cheng, Peng, Guo, Zhanjun, Yang, Junya, Li, Changjun, Wu, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10310746/
https://www.ncbi.nlm.nih.gov/pubmed/37385994
http://dx.doi.org/10.1038/s41419-023-05909-7

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