Cargando…

GABA decrease is associated with degraded neural specificity in the visual cortex of glaucoma patients

Glaucoma is an age-related neurodegenerative disease of the visual system, affecting both the eye and the brain. Yet its underlying metabolic mechanisms and neurobehavioral relevance remain largely unclear. Here, using proton magnetic resonance spectroscopy and functional magnetic resonance imaging,...

Descripción completa

Detalles Bibliográficos
Autores principales: Bang, Ji Won, Parra, Carlos, Yu, Kevin, Wollstein, Gadi, Schuman, Joel S., Chan, Kevin C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10310759/
https://www.ncbi.nlm.nih.gov/pubmed/37386293
http://dx.doi.org/10.1038/s42003-023-04918-8
_version_ 1785066602230710272
author Bang, Ji Won
Parra, Carlos
Yu, Kevin
Wollstein, Gadi
Schuman, Joel S.
Chan, Kevin C.
author_facet Bang, Ji Won
Parra, Carlos
Yu, Kevin
Wollstein, Gadi
Schuman, Joel S.
Chan, Kevin C.
author_sort Bang, Ji Won
collection PubMed
description Glaucoma is an age-related neurodegenerative disease of the visual system, affecting both the eye and the brain. Yet its underlying metabolic mechanisms and neurobehavioral relevance remain largely unclear. Here, using proton magnetic resonance spectroscopy and functional magnetic resonance imaging, we investigated the GABAergic and glutamatergic systems in the visual cortex of glaucoma patients, as well as neural specificity, which is shaped by GABA and glutamate signals and underlies efficient sensory and cognitive functions. Our study shows that among the older adults, both GABA and glutamate levels decrease with increasing glaucoma severity regardless of age. Further, our study shows that the reduction of GABA but not glutamate predicts the neural specificity. This association is independent of the impairments on the retina structure, age, and the gray matter volume of the visual cortex. Our results suggest that glaucoma-specific decline of GABA undermines neural specificity in the visual cortex and that targeting GABA could improve the neural specificity in glaucoma.
format Online
Article
Text
id pubmed-10310759
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-103107592023-07-01 GABA decrease is associated with degraded neural specificity in the visual cortex of glaucoma patients Bang, Ji Won Parra, Carlos Yu, Kevin Wollstein, Gadi Schuman, Joel S. Chan, Kevin C. Commun Biol Article Glaucoma is an age-related neurodegenerative disease of the visual system, affecting both the eye and the brain. Yet its underlying metabolic mechanisms and neurobehavioral relevance remain largely unclear. Here, using proton magnetic resonance spectroscopy and functional magnetic resonance imaging, we investigated the GABAergic and glutamatergic systems in the visual cortex of glaucoma patients, as well as neural specificity, which is shaped by GABA and glutamate signals and underlies efficient sensory and cognitive functions. Our study shows that among the older adults, both GABA and glutamate levels decrease with increasing glaucoma severity regardless of age. Further, our study shows that the reduction of GABA but not glutamate predicts the neural specificity. This association is independent of the impairments on the retina structure, age, and the gray matter volume of the visual cortex. Our results suggest that glaucoma-specific decline of GABA undermines neural specificity in the visual cortex and that targeting GABA could improve the neural specificity in glaucoma. Nature Publishing Group UK 2023-06-29 /pmc/articles/PMC10310759/ /pubmed/37386293 http://dx.doi.org/10.1038/s42003-023-04918-8 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Bang, Ji Won
Parra, Carlos
Yu, Kevin
Wollstein, Gadi
Schuman, Joel S.
Chan, Kevin C.
GABA decrease is associated with degraded neural specificity in the visual cortex of glaucoma patients
title GABA decrease is associated with degraded neural specificity in the visual cortex of glaucoma patients
title_full GABA decrease is associated with degraded neural specificity in the visual cortex of glaucoma patients
title_fullStr GABA decrease is associated with degraded neural specificity in the visual cortex of glaucoma patients
title_full_unstemmed GABA decrease is associated with degraded neural specificity in the visual cortex of glaucoma patients
title_short GABA decrease is associated with degraded neural specificity in the visual cortex of glaucoma patients
title_sort gaba decrease is associated with degraded neural specificity in the visual cortex of glaucoma patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10310759/
https://www.ncbi.nlm.nih.gov/pubmed/37386293
http://dx.doi.org/10.1038/s42003-023-04918-8
work_keys_str_mv AT bangjiwon gabadecreaseisassociatedwithdegradedneuralspecificityinthevisualcortexofglaucomapatients
AT parracarlos gabadecreaseisassociatedwithdegradedneuralspecificityinthevisualcortexofglaucomapatients
AT yukevin gabadecreaseisassociatedwithdegradedneuralspecificityinthevisualcortexofglaucomapatients
AT wollsteingadi gabadecreaseisassociatedwithdegradedneuralspecificityinthevisualcortexofglaucomapatients
AT schumanjoels gabadecreaseisassociatedwithdegradedneuralspecificityinthevisualcortexofglaucomapatients
AT chankevinc gabadecreaseisassociatedwithdegradedneuralspecificityinthevisualcortexofglaucomapatients