Mechanisms of fever-induced QT prolongation and torsades de pointes in patients with KCNH2 mutation

AIMS: Patients with particular mutations of type-2 long QT syndrome (LQT2) are at an increased risk for malignant arrhythmia during fever. This study aimed to determine the mechanism by which KCNH2 mutations cause fever-induced QT prolongation and torsades de pointes (TdP). METHODS AND RESULTS: We e...

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Detalles Bibliográficos
Autores principales: Usuda, Keisuke, Hayashi, Kenshi, Nakajima, Tadashi, Kurata, Yasutaka, Cui, Shihe, Kusayama, Takashi, Tsuda, Toyonobu, Tada, Hayato, Kato, Takeshi, Sakata, Kenji, Usui, Soichiro, Fujino, Noboru, Tanaka, Yoshihiro, Kaneko, Yoshiaki, Kurabayashi, Masahiko, Tange, Shoichi, Saito, Takekatsu, Ohta, Kunio, Yamagishi, Masakazu, Takamura, Masayuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Basic Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10310978/
https://www.ncbi.nlm.nih.gov/pubmed/37386841
http://dx.doi.org/10.1093/europace/euad161

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