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Urinary Bladder Carcinoma in Females: A Clinico-Pathological Assessment

Background: Urinary bladder cancer is an uncommon cancer in females. Despite not being an infrequent encounter, female bladder cancer remains a poorly defined entity. There is a paucity of literature regarding bladder cancer in females, especially in North India. Objective: This study aims to evalua...

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Autores principales: Gupta, Rahul, Khan, Suhail M, Mahajan, Manik, Sharma, Poonam, Mahajan, Arti
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10311036/
https://www.ncbi.nlm.nih.gov/pubmed/37398730
http://dx.doi.org/10.7759/cureus.39753
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author Gupta, Rahul
Khan, Suhail M
Mahajan, Manik
Sharma, Poonam
Mahajan, Arti
author_facet Gupta, Rahul
Khan, Suhail M
Mahajan, Manik
Sharma, Poonam
Mahajan, Arti
author_sort Gupta, Rahul
collection PubMed
description Background: Urinary bladder cancer is an uncommon cancer in females. Despite not being an infrequent encounter, female bladder cancer remains a poorly defined entity. There is a paucity of literature regarding bladder cancer in females, especially in North India. Objective: This study aims to evaluate the clinico-pathological profile of bladder cancer in female patients managed at a single centre in north India. Materials and methods: This retrospective observational study was carried out in a tertiary care centre in North India. Medical records and a database of female patients with bladder cancer treated between January 2012 and January 2021 were retrieved. Data regarding age, duration of disease, associated comorbidity, histopathological variants, and outcomes were studied. Results: Out of 56 female patients with bladder masses, 55 had transitional cell carcinoma (TCC), while one had pheochromocytoma. Painless hematuria (80.3%) was the commonest presentation. At the time of presentation, 5 patients (9.1%) had muscle-invasive bladder cancer (T2-T4), while 50 patients had non-muscle-invasive disease, out of which 31 (56.4%) patients had high-grade and 19 (34.5%) patients had low-grade papillary carcinoma. Twenty-three patients (41.8%) had a history of exposure to domestic chulha (open wood-burning cooking stove), and 11 patients (20%) were smokers; six patients (10.9%) were exposed to both risk factors. Conclusions: Female bladder cancer was most prevalent in the sixth decade of life, with the majority of patients having a high-grade but non-muscle-invasive disease. Of all the risk factors, chulha exposure was the main risk factor in the aetiology of female bladder cancer.
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spelling pubmed-103110362023-07-01 Urinary Bladder Carcinoma in Females: A Clinico-Pathological Assessment Gupta, Rahul Khan, Suhail M Mahajan, Manik Sharma, Poonam Mahajan, Arti Cureus Radiology Background: Urinary bladder cancer is an uncommon cancer in females. Despite not being an infrequent encounter, female bladder cancer remains a poorly defined entity. There is a paucity of literature regarding bladder cancer in females, especially in North India. Objective: This study aims to evaluate the clinico-pathological profile of bladder cancer in female patients managed at a single centre in north India. Materials and methods: This retrospective observational study was carried out in a tertiary care centre in North India. Medical records and a database of female patients with bladder cancer treated between January 2012 and January 2021 were retrieved. Data regarding age, duration of disease, associated comorbidity, histopathological variants, and outcomes were studied. Results: Out of 56 female patients with bladder masses, 55 had transitional cell carcinoma (TCC), while one had pheochromocytoma. Painless hematuria (80.3%) was the commonest presentation. At the time of presentation, 5 patients (9.1%) had muscle-invasive bladder cancer (T2-T4), while 50 patients had non-muscle-invasive disease, out of which 31 (56.4%) patients had high-grade and 19 (34.5%) patients had low-grade papillary carcinoma. Twenty-three patients (41.8%) had a history of exposure to domestic chulha (open wood-burning cooking stove), and 11 patients (20%) were smokers; six patients (10.9%) were exposed to both risk factors. Conclusions: Female bladder cancer was most prevalent in the sixth decade of life, with the majority of patients having a high-grade but non-muscle-invasive disease. Of all the risk factors, chulha exposure was the main risk factor in the aetiology of female bladder cancer. Cureus 2023-05-30 /pmc/articles/PMC10311036/ /pubmed/37398730 http://dx.doi.org/10.7759/cureus.39753 Text en Copyright © 2023, Gupta et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Radiology
Gupta, Rahul
Khan, Suhail M
Mahajan, Manik
Sharma, Poonam
Mahajan, Arti
Urinary Bladder Carcinoma in Females: A Clinico-Pathological Assessment
title Urinary Bladder Carcinoma in Females: A Clinico-Pathological Assessment
title_full Urinary Bladder Carcinoma in Females: A Clinico-Pathological Assessment
title_fullStr Urinary Bladder Carcinoma in Females: A Clinico-Pathological Assessment
title_full_unstemmed Urinary Bladder Carcinoma in Females: A Clinico-Pathological Assessment
title_short Urinary Bladder Carcinoma in Females: A Clinico-Pathological Assessment
title_sort urinary bladder carcinoma in females: a clinico-pathological assessment
topic Radiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10311036/
https://www.ncbi.nlm.nih.gov/pubmed/37398730
http://dx.doi.org/10.7759/cureus.39753
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