PD-L1 expression is regulated by ATP-binding of the ERBB3 pseudokinase domain

How PD-L1 expression is regulated in cancer is poorly understood. Here, we report that the ATP-binding activity of ERBB3 pseudokinase regulates PD-L1 gene expression in colorectal cancers (CRCs). ERBB3 is one of the four members of the EGF receptor family, all with protein tyrosine kinase domains. E...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Yamu, Liu, Zhonghua, Zhao, Yiqing, Yang, Jie, Xiao, Tsan Sam, Conlon, Ronald A., Wang, Zhenghe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chongqing Medical University 2022
Materias:
Full Length Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10311099/
https://www.ncbi.nlm.nih.gov/pubmed/37397533
http://dx.doi.org/10.1016/j.gendis.2022.11.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10311099/
https://www.ncbi.nlm.nih.gov/pubmed/37397533
http://dx.doi.org/10.1016/j.gendis.2022.11.003

Ejemplares similares