The role of TGF-β in the tumor microenvironment of pancreatic cancer

Pancreatic cancer (PC) is an aggressive malignant tumor with low rate of surgical resection and poor prognosis. Transforming growth factor-β (TGF-β) is a cytokine that has both protumor and antitumor activities, depending on tumor microenvironment. The interaction between TGF-β signaling and the tum...

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Detalles Bibliográficos
Autores principales: Luo, Qiang, Hu, Ziquan, Zhao, Hongcheng, Fan, Yanmei, Tu, Xiancong, Wang, Yueqing, Liu, Xiaowen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chongqing Medical University 2022
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10311106/
https://www.ncbi.nlm.nih.gov/pubmed/37397548
http://dx.doi.org/10.1016/j.gendis.2022.10.019
Descripción
Sumario:Pancreatic cancer (PC) is an aggressive malignant tumor with low rate of surgical resection and poor prognosis. Transforming growth factor-β (TGF-β) is a cytokine that has both protumor and antitumor activities, depending on tumor microenvironment. The interaction between TGF-β signaling and the tumor microenvironment in PC is complex. Here, we reviewed the role of TGF-β in the tumor microenvironment of PC, highlighting producers of TGF-β and TGF-β responders in the tumor microenvironment of PC.

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