The role of TGF-β in the tumor microenvironment of pancreatic cancer

Pancreatic cancer (PC) is an aggressive malignant tumor with low rate of surgical resection and poor prognosis. Transforming growth factor-β (TGF-β) is a cytokine that has both protumor and antitumor activities, depending on tumor microenvironment. The interaction between TGF-β signaling and the tum...

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Detalles Bibliográficos
Autores principales: Luo, Qiang, Hu, Ziquan, Zhao, Hongcheng, Fan, Yanmei, Tu, Xiancong, Wang, Yueqing, Liu, Xiaowen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chongqing Medical University 2022
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10311106/
https://www.ncbi.nlm.nih.gov/pubmed/37397548
http://dx.doi.org/10.1016/j.gendis.2022.10.019
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author Luo, Qiang
Hu, Ziquan
Zhao, Hongcheng
Fan, Yanmei
Tu, Xiancong
Wang, Yueqing
Liu, Xiaowen
author_facet Luo, Qiang
Hu, Ziquan
Zhao, Hongcheng
Fan, Yanmei
Tu, Xiancong
Wang, Yueqing
Liu, Xiaowen
author_sort Luo, Qiang
collection PubMed
description Pancreatic cancer (PC) is an aggressive malignant tumor with low rate of surgical resection and poor prognosis. Transforming growth factor-β (TGF-β) is a cytokine that has both protumor and antitumor activities, depending on tumor microenvironment. The interaction between TGF-β signaling and the tumor microenvironment in PC is complex. Here, we reviewed the role of TGF-β in the tumor microenvironment of PC, highlighting producers of TGF-β and TGF-β responders in the tumor microenvironment of PC.
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spelling pubmed-103111062023-07-01 The role of TGF-β in the tumor microenvironment of pancreatic cancer Luo, Qiang Hu, Ziquan Zhao, Hongcheng Fan, Yanmei Tu, Xiancong Wang, Yueqing Liu, Xiaowen Genes Dis Review Article Pancreatic cancer (PC) is an aggressive malignant tumor with low rate of surgical resection and poor prognosis. Transforming growth factor-β (TGF-β) is a cytokine that has both protumor and antitumor activities, depending on tumor microenvironment. The interaction between TGF-β signaling and the tumor microenvironment in PC is complex. Here, we reviewed the role of TGF-β in the tumor microenvironment of PC, highlighting producers of TGF-β and TGF-β responders in the tumor microenvironment of PC. Chongqing Medical University 2022-11-19 /pmc/articles/PMC10311106/ /pubmed/37397548 http://dx.doi.org/10.1016/j.gendis.2022.10.019 Text en © 2022 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Luo, Qiang
Hu, Ziquan
Zhao, Hongcheng
Fan, Yanmei
Tu, Xiancong
Wang, Yueqing
Liu, Xiaowen
The role of TGF-β in the tumor microenvironment of pancreatic cancer
title The role of TGF-β in the tumor microenvironment of pancreatic cancer
title_full The role of TGF-β in the tumor microenvironment of pancreatic cancer
title_fullStr The role of TGF-β in the tumor microenvironment of pancreatic cancer
title_full_unstemmed The role of TGF-β in the tumor microenvironment of pancreatic cancer
title_short The role of TGF-β in the tumor microenvironment of pancreatic cancer
title_sort role of tgf-β in the tumor microenvironment of pancreatic cancer
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10311106/
https://www.ncbi.nlm.nih.gov/pubmed/37397548
http://dx.doi.org/10.1016/j.gendis.2022.10.019
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