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Development of cortical folds in the human brain: An attempt to review biological hypotheses, early neuroimaging investigations and functional correlates()

The folding of the human brain mostly takes place in utero, making it challenging to study. After a few pioneer studies looking into it in post-mortem foetal specimen, modern approaches based on neuroimaging have allowed the community to investigate the folding process in vivo, its normal progressio...

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Detalles Bibliográficos
Autores principales: de Vareilles, H., Rivière, D., Mangin, JF, Dubois, J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10311195/
https://www.ncbi.nlm.nih.gov/pubmed/37141790
http://dx.doi.org/10.1016/j.dcn.2023.101249
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author de Vareilles, H.
Rivière, D.
Mangin, JF
Dubois, J.
author_facet de Vareilles, H.
Rivière, D.
Mangin, JF
Dubois, J.
author_sort de Vareilles, H.
collection PubMed
description The folding of the human brain mostly takes place in utero, making it challenging to study. After a few pioneer studies looking into it in post-mortem foetal specimen, modern approaches based on neuroimaging have allowed the community to investigate the folding process in vivo, its normal progression, its early disturbances, and its relationship to later functional outcomes. In this review article, we aimed to first give an overview of the current hypotheses on the mechanisms governing cortical folding. After describing the methodological difficulties raised by its study in fetuses, neonates and infants with magnetic resonance imaging (MRI), we reported our current understanding of sulcal pattern emergence in the developing brain. We then highlighted the functional relevance of early sulcal development, through recent insights about hemispheric asymmetries and early factors influencing this dynamic such as prematurity. Finally, we outlined how longitudinal studies have started to relate early folding markers and the child’s sensorimotor and cognitive outcome. Through this review, we hope to raise awareness on the potential of studying early sulcal patterns both from a fundamental and clinical perspective, as a window into early neurodevelopment and plasticity in relation to growth in utero and postnatal environment of the child.
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spelling pubmed-103111952023-07-01 Development of cortical folds in the human brain: An attempt to review biological hypotheses, early neuroimaging investigations and functional correlates() de Vareilles, H. Rivière, D. Mangin, JF Dubois, J. Dev Cogn Neurosci Articles from the Special Issue on Flux 2021; Edited by Beatriz Luna, Nikolaus Steinbeis; Duncan Astle; Alexandra Cohen; Yee Lee Shing The folding of the human brain mostly takes place in utero, making it challenging to study. After a few pioneer studies looking into it in post-mortem foetal specimen, modern approaches based on neuroimaging have allowed the community to investigate the folding process in vivo, its normal progression, its early disturbances, and its relationship to later functional outcomes. In this review article, we aimed to first give an overview of the current hypotheses on the mechanisms governing cortical folding. After describing the methodological difficulties raised by its study in fetuses, neonates and infants with magnetic resonance imaging (MRI), we reported our current understanding of sulcal pattern emergence in the developing brain. We then highlighted the functional relevance of early sulcal development, through recent insights about hemispheric asymmetries and early factors influencing this dynamic such as prematurity. Finally, we outlined how longitudinal studies have started to relate early folding markers and the child’s sensorimotor and cognitive outcome. Through this review, we hope to raise awareness on the potential of studying early sulcal patterns both from a fundamental and clinical perspective, as a window into early neurodevelopment and plasticity in relation to growth in utero and postnatal environment of the child. Elsevier 2023-04-25 /pmc/articles/PMC10311195/ /pubmed/37141790 http://dx.doi.org/10.1016/j.dcn.2023.101249 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Articles from the Special Issue on Flux 2021; Edited by Beatriz Luna, Nikolaus Steinbeis; Duncan Astle; Alexandra Cohen; Yee Lee Shing
de Vareilles, H.
Rivière, D.
Mangin, JF
Dubois, J.
Development of cortical folds in the human brain: An attempt to review biological hypotheses, early neuroimaging investigations and functional correlates()
title Development of cortical folds in the human brain: An attempt to review biological hypotheses, early neuroimaging investigations and functional correlates()
title_full Development of cortical folds in the human brain: An attempt to review biological hypotheses, early neuroimaging investigations and functional correlates()
title_fullStr Development of cortical folds in the human brain: An attempt to review biological hypotheses, early neuroimaging investigations and functional correlates()
title_full_unstemmed Development of cortical folds in the human brain: An attempt to review biological hypotheses, early neuroimaging investigations and functional correlates()
title_short Development of cortical folds in the human brain: An attempt to review biological hypotheses, early neuroimaging investigations and functional correlates()
title_sort development of cortical folds in the human brain: an attempt to review biological hypotheses, early neuroimaging investigations and functional correlates()
topic Articles from the Special Issue on Flux 2021; Edited by Beatriz Luna, Nikolaus Steinbeis; Duncan Astle; Alexandra Cohen; Yee Lee Shing
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10311195/
https://www.ncbi.nlm.nih.gov/pubmed/37141790
http://dx.doi.org/10.1016/j.dcn.2023.101249
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