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Effect of atrial fibrillation on outcomes in patients with anterior circulation occlusion stroke receiving endovascular therapy

OBJECTIVE: Atrial fibrillation is one of the major risk factors of ischemic stroke. Endovascular thrombectomy (EVT) has become the standard treatment for acute ischemic stroke with large vessel occlusion. However, data regarding the impact of AF on the outcome of patients with acute ischemic stroke...

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Autores principales: Wu, Weijuan, Pitton Rissardo, Jamir, Nguyen, Thanh N., Mofatteh, Mohammad, Wei, Hongquan, Liebeskind, David S., Yang, Shuiquan, Li, Wanquan, Pan, Wanling, Zhou, Sijie, Lai, Yuzheng, Gao, Jianfang, Wang, Jian, Ouyang, Ziqi, Mai, Yuzhen, Meng, Heng, Chen, Yimin, Liao, Xuxing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10311510/
https://www.ncbi.nlm.nih.gov/pubmed/37396665
http://dx.doi.org/10.3389/fnagi.2023.1160265
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author Wu, Weijuan
Pitton Rissardo, Jamir
Nguyen, Thanh N.
Mofatteh, Mohammad
Wei, Hongquan
Liebeskind, David S.
Yang, Shuiquan
Li, Wanquan
Pan, Wanling
Zhou, Sijie
Lai, Yuzheng
Gao, Jianfang
Wang, Jian
Ouyang, Ziqi
Mai, Yuzhen
Meng, Heng
Chen, Yimin
Liao, Xuxing
author_facet Wu, Weijuan
Pitton Rissardo, Jamir
Nguyen, Thanh N.
Mofatteh, Mohammad
Wei, Hongquan
Liebeskind, David S.
Yang, Shuiquan
Li, Wanquan
Pan, Wanling
Zhou, Sijie
Lai, Yuzheng
Gao, Jianfang
Wang, Jian
Ouyang, Ziqi
Mai, Yuzhen
Meng, Heng
Chen, Yimin
Liao, Xuxing
author_sort Wu, Weijuan
collection PubMed
description OBJECTIVE: Atrial fibrillation is one of the major risk factors of ischemic stroke. Endovascular thrombectomy (EVT) has become the standard treatment for acute ischemic stroke with large vessel occlusion. However, data regarding the impact of AF on the outcome of patients with acute ischemic stroke treated with mechanical thrombectomy are controversial. The aim of our study was to determine whether atrial fibrillation modifies the functional outcome of patients with anterior circulation acute ischemic stroke receiving EVT. METHODS: We reviewed 273 eligible patients receiving EVT from January 2019 to January 2022 from 3 comprehensive Chinese stroke centers, of whom 221 patients were recruited. Demographics, clinical, radiological and treatment characteristics, safety outcomes, and functional outcomes were collected. Modified Rankin scale (mRS) score ≤ 2 at 90 days was defined as a good functional outcome. RESULTS: In our cohort, 79 patients (35.74%) were eventually found to have AF. Patients with AF were elder (70.08 ± 11.72 vs. 61.82 ± 13.48 years, p = 0.000) and less likely to be males (54.43 vs. 73.94%, p = 0.03). The significant reperfusion rate (modified thrombolysis in cerebral infarction 2b-3) was 73.42 and 83.80% in patients with and without AF, respectively (p = 0.064). The good functional outcome (90-day modified Rankin scale: 0 to 2) rate was 39.24 and 44.37% in patients with and without AF, respectively (p = 0.460) after adjusting multiple confounding factors. There was no difference in the presence of symptomatic intracerebral hemorrhage between the two groups (10.13 vs. 12.68%, p = 0.573). CONCLUSION: Despite their older age, AF patients achieved similar outcomes as non-AF patients with anterior circulation occlusion treated with endovascular therapy.
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spelling pubmed-103115102023-07-01 Effect of atrial fibrillation on outcomes in patients with anterior circulation occlusion stroke receiving endovascular therapy Wu, Weijuan Pitton Rissardo, Jamir Nguyen, Thanh N. Mofatteh, Mohammad Wei, Hongquan Liebeskind, David S. Yang, Shuiquan Li, Wanquan Pan, Wanling Zhou, Sijie Lai, Yuzheng Gao, Jianfang Wang, Jian Ouyang, Ziqi Mai, Yuzhen Meng, Heng Chen, Yimin Liao, Xuxing Front Aging Neurosci Neuroscience OBJECTIVE: Atrial fibrillation is one of the major risk factors of ischemic stroke. Endovascular thrombectomy (EVT) has become the standard treatment for acute ischemic stroke with large vessel occlusion. However, data regarding the impact of AF on the outcome of patients with acute ischemic stroke treated with mechanical thrombectomy are controversial. The aim of our study was to determine whether atrial fibrillation modifies the functional outcome of patients with anterior circulation acute ischemic stroke receiving EVT. METHODS: We reviewed 273 eligible patients receiving EVT from January 2019 to January 2022 from 3 comprehensive Chinese stroke centers, of whom 221 patients were recruited. Demographics, clinical, radiological and treatment characteristics, safety outcomes, and functional outcomes were collected. Modified Rankin scale (mRS) score ≤ 2 at 90 days was defined as a good functional outcome. RESULTS: In our cohort, 79 patients (35.74%) were eventually found to have AF. Patients with AF were elder (70.08 ± 11.72 vs. 61.82 ± 13.48 years, p = 0.000) and less likely to be males (54.43 vs. 73.94%, p = 0.03). The significant reperfusion rate (modified thrombolysis in cerebral infarction 2b-3) was 73.42 and 83.80% in patients with and without AF, respectively (p = 0.064). The good functional outcome (90-day modified Rankin scale: 0 to 2) rate was 39.24 and 44.37% in patients with and without AF, respectively (p = 0.460) after adjusting multiple confounding factors. There was no difference in the presence of symptomatic intracerebral hemorrhage between the two groups (10.13 vs. 12.68%, p = 0.573). CONCLUSION: Despite their older age, AF patients achieved similar outcomes as non-AF patients with anterior circulation occlusion treated with endovascular therapy. Frontiers Media S.A. 2023-06-15 /pmc/articles/PMC10311510/ /pubmed/37396665 http://dx.doi.org/10.3389/fnagi.2023.1160265 Text en Copyright © 2023 Wu, Pitton Rissardo, Nguyen, Mofatteh, Wei, Liebeskind, Yang, Li, Pan, Zhou, Lai, Gao, Wang, Ouyang, Mai, Meng, Chen and Liao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Wu, Weijuan
Pitton Rissardo, Jamir
Nguyen, Thanh N.
Mofatteh, Mohammad
Wei, Hongquan
Liebeskind, David S.
Yang, Shuiquan
Li, Wanquan
Pan, Wanling
Zhou, Sijie
Lai, Yuzheng
Gao, Jianfang
Wang, Jian
Ouyang, Ziqi
Mai, Yuzhen
Meng, Heng
Chen, Yimin
Liao, Xuxing
Effect of atrial fibrillation on outcomes in patients with anterior circulation occlusion stroke receiving endovascular therapy
title Effect of atrial fibrillation on outcomes in patients with anterior circulation occlusion stroke receiving endovascular therapy
title_full Effect of atrial fibrillation on outcomes in patients with anterior circulation occlusion stroke receiving endovascular therapy
title_fullStr Effect of atrial fibrillation on outcomes in patients with anterior circulation occlusion stroke receiving endovascular therapy
title_full_unstemmed Effect of atrial fibrillation on outcomes in patients with anterior circulation occlusion stroke receiving endovascular therapy
title_short Effect of atrial fibrillation on outcomes in patients with anterior circulation occlusion stroke receiving endovascular therapy
title_sort effect of atrial fibrillation on outcomes in patients with anterior circulation occlusion stroke receiving endovascular therapy
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10311510/
https://www.ncbi.nlm.nih.gov/pubmed/37396665
http://dx.doi.org/10.3389/fnagi.2023.1160265
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