Cargando…
Effect of atrial fibrillation on outcomes in patients with anterior circulation occlusion stroke receiving endovascular therapy
OBJECTIVE: Atrial fibrillation is one of the major risk factors of ischemic stroke. Endovascular thrombectomy (EVT) has become the standard treatment for acute ischemic stroke with large vessel occlusion. However, data regarding the impact of AF on the outcome of patients with acute ischemic stroke...
Autores principales: | , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10311510/ https://www.ncbi.nlm.nih.gov/pubmed/37396665 http://dx.doi.org/10.3389/fnagi.2023.1160265 |
_version_ | 1785066756681760768 |
---|---|
author | Wu, Weijuan Pitton Rissardo, Jamir Nguyen, Thanh N. Mofatteh, Mohammad Wei, Hongquan Liebeskind, David S. Yang, Shuiquan Li, Wanquan Pan, Wanling Zhou, Sijie Lai, Yuzheng Gao, Jianfang Wang, Jian Ouyang, Ziqi Mai, Yuzhen Meng, Heng Chen, Yimin Liao, Xuxing |
author_facet | Wu, Weijuan Pitton Rissardo, Jamir Nguyen, Thanh N. Mofatteh, Mohammad Wei, Hongquan Liebeskind, David S. Yang, Shuiquan Li, Wanquan Pan, Wanling Zhou, Sijie Lai, Yuzheng Gao, Jianfang Wang, Jian Ouyang, Ziqi Mai, Yuzhen Meng, Heng Chen, Yimin Liao, Xuxing |
author_sort | Wu, Weijuan |
collection | PubMed |
description | OBJECTIVE: Atrial fibrillation is one of the major risk factors of ischemic stroke. Endovascular thrombectomy (EVT) has become the standard treatment for acute ischemic stroke with large vessel occlusion. However, data regarding the impact of AF on the outcome of patients with acute ischemic stroke treated with mechanical thrombectomy are controversial. The aim of our study was to determine whether atrial fibrillation modifies the functional outcome of patients with anterior circulation acute ischemic stroke receiving EVT. METHODS: We reviewed 273 eligible patients receiving EVT from January 2019 to January 2022 from 3 comprehensive Chinese stroke centers, of whom 221 patients were recruited. Demographics, clinical, radiological and treatment characteristics, safety outcomes, and functional outcomes were collected. Modified Rankin scale (mRS) score ≤ 2 at 90 days was defined as a good functional outcome. RESULTS: In our cohort, 79 patients (35.74%) were eventually found to have AF. Patients with AF were elder (70.08 ± 11.72 vs. 61.82 ± 13.48 years, p = 0.000) and less likely to be males (54.43 vs. 73.94%, p = 0.03). The significant reperfusion rate (modified thrombolysis in cerebral infarction 2b-3) was 73.42 and 83.80% in patients with and without AF, respectively (p = 0.064). The good functional outcome (90-day modified Rankin scale: 0 to 2) rate was 39.24 and 44.37% in patients with and without AF, respectively (p = 0.460) after adjusting multiple confounding factors. There was no difference in the presence of symptomatic intracerebral hemorrhage between the two groups (10.13 vs. 12.68%, p = 0.573). CONCLUSION: Despite their older age, AF patients achieved similar outcomes as non-AF patients with anterior circulation occlusion treated with endovascular therapy. |
format | Online Article Text |
id | pubmed-10311510 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-103115102023-07-01 Effect of atrial fibrillation on outcomes in patients with anterior circulation occlusion stroke receiving endovascular therapy Wu, Weijuan Pitton Rissardo, Jamir Nguyen, Thanh N. Mofatteh, Mohammad Wei, Hongquan Liebeskind, David S. Yang, Shuiquan Li, Wanquan Pan, Wanling Zhou, Sijie Lai, Yuzheng Gao, Jianfang Wang, Jian Ouyang, Ziqi Mai, Yuzhen Meng, Heng Chen, Yimin Liao, Xuxing Front Aging Neurosci Neuroscience OBJECTIVE: Atrial fibrillation is one of the major risk factors of ischemic stroke. Endovascular thrombectomy (EVT) has become the standard treatment for acute ischemic stroke with large vessel occlusion. However, data regarding the impact of AF on the outcome of patients with acute ischemic stroke treated with mechanical thrombectomy are controversial. The aim of our study was to determine whether atrial fibrillation modifies the functional outcome of patients with anterior circulation acute ischemic stroke receiving EVT. METHODS: We reviewed 273 eligible patients receiving EVT from January 2019 to January 2022 from 3 comprehensive Chinese stroke centers, of whom 221 patients were recruited. Demographics, clinical, radiological and treatment characteristics, safety outcomes, and functional outcomes were collected. Modified Rankin scale (mRS) score ≤ 2 at 90 days was defined as a good functional outcome. RESULTS: In our cohort, 79 patients (35.74%) were eventually found to have AF. Patients with AF were elder (70.08 ± 11.72 vs. 61.82 ± 13.48 years, p = 0.000) and less likely to be males (54.43 vs. 73.94%, p = 0.03). The significant reperfusion rate (modified thrombolysis in cerebral infarction 2b-3) was 73.42 and 83.80% in patients with and without AF, respectively (p = 0.064). The good functional outcome (90-day modified Rankin scale: 0 to 2) rate was 39.24 and 44.37% in patients with and without AF, respectively (p = 0.460) after adjusting multiple confounding factors. There was no difference in the presence of symptomatic intracerebral hemorrhage between the two groups (10.13 vs. 12.68%, p = 0.573). CONCLUSION: Despite their older age, AF patients achieved similar outcomes as non-AF patients with anterior circulation occlusion treated with endovascular therapy. Frontiers Media S.A. 2023-06-15 /pmc/articles/PMC10311510/ /pubmed/37396665 http://dx.doi.org/10.3389/fnagi.2023.1160265 Text en Copyright © 2023 Wu, Pitton Rissardo, Nguyen, Mofatteh, Wei, Liebeskind, Yang, Li, Pan, Zhou, Lai, Gao, Wang, Ouyang, Mai, Meng, Chen and Liao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Wu, Weijuan Pitton Rissardo, Jamir Nguyen, Thanh N. Mofatteh, Mohammad Wei, Hongquan Liebeskind, David S. Yang, Shuiquan Li, Wanquan Pan, Wanling Zhou, Sijie Lai, Yuzheng Gao, Jianfang Wang, Jian Ouyang, Ziqi Mai, Yuzhen Meng, Heng Chen, Yimin Liao, Xuxing Effect of atrial fibrillation on outcomes in patients with anterior circulation occlusion stroke receiving endovascular therapy |
title | Effect of atrial fibrillation on outcomes in patients with anterior circulation occlusion stroke receiving endovascular therapy |
title_full | Effect of atrial fibrillation on outcomes in patients with anterior circulation occlusion stroke receiving endovascular therapy |
title_fullStr | Effect of atrial fibrillation on outcomes in patients with anterior circulation occlusion stroke receiving endovascular therapy |
title_full_unstemmed | Effect of atrial fibrillation on outcomes in patients with anterior circulation occlusion stroke receiving endovascular therapy |
title_short | Effect of atrial fibrillation on outcomes in patients with anterior circulation occlusion stroke receiving endovascular therapy |
title_sort | effect of atrial fibrillation on outcomes in patients with anterior circulation occlusion stroke receiving endovascular therapy |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10311510/ https://www.ncbi.nlm.nih.gov/pubmed/37396665 http://dx.doi.org/10.3389/fnagi.2023.1160265 |
work_keys_str_mv | AT wuweijuan effectofatrialfibrillationonoutcomesinpatientswithanteriorcirculationocclusionstrokereceivingendovasculartherapy AT pittonrissardojamir effectofatrialfibrillationonoutcomesinpatientswithanteriorcirculationocclusionstrokereceivingendovasculartherapy AT nguyenthanhn effectofatrialfibrillationonoutcomesinpatientswithanteriorcirculationocclusionstrokereceivingendovasculartherapy AT mofattehmohammad effectofatrialfibrillationonoutcomesinpatientswithanteriorcirculationocclusionstrokereceivingendovasculartherapy AT weihongquan effectofatrialfibrillationonoutcomesinpatientswithanteriorcirculationocclusionstrokereceivingendovasculartherapy AT liebeskinddavids effectofatrialfibrillationonoutcomesinpatientswithanteriorcirculationocclusionstrokereceivingendovasculartherapy AT yangshuiquan effectofatrialfibrillationonoutcomesinpatientswithanteriorcirculationocclusionstrokereceivingendovasculartherapy AT liwanquan effectofatrialfibrillationonoutcomesinpatientswithanteriorcirculationocclusionstrokereceivingendovasculartherapy AT panwanling effectofatrialfibrillationonoutcomesinpatientswithanteriorcirculationocclusionstrokereceivingendovasculartherapy AT zhousijie effectofatrialfibrillationonoutcomesinpatientswithanteriorcirculationocclusionstrokereceivingendovasculartherapy AT laiyuzheng effectofatrialfibrillationonoutcomesinpatientswithanteriorcirculationocclusionstrokereceivingendovasculartherapy AT gaojianfang effectofatrialfibrillationonoutcomesinpatientswithanteriorcirculationocclusionstrokereceivingendovasculartherapy AT wangjian effectofatrialfibrillationonoutcomesinpatientswithanteriorcirculationocclusionstrokereceivingendovasculartherapy AT ouyangziqi effectofatrialfibrillationonoutcomesinpatientswithanteriorcirculationocclusionstrokereceivingendovasculartherapy AT maiyuzhen effectofatrialfibrillationonoutcomesinpatientswithanteriorcirculationocclusionstrokereceivingendovasculartherapy AT mengheng effectofatrialfibrillationonoutcomesinpatientswithanteriorcirculationocclusionstrokereceivingendovasculartherapy AT chenyimin effectofatrialfibrillationonoutcomesinpatientswithanteriorcirculationocclusionstrokereceivingendovasculartherapy AT liaoxuxing effectofatrialfibrillationonoutcomesinpatientswithanteriorcirculationocclusionstrokereceivingendovasculartherapy |