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Dynamic regulation of the extracellular matrix in reward memory processes: a question of time

Substance use disorders are a global health problem with increasing prevalence resulting in significant socioeconomic burden and increased mortality. Converging lines of evidence point to a critical role of brain extracellular matrix (ECM) molecules in the pathophysiology of substance use disorders....

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Detalles Bibliográficos
Autores principales: Valeri, Jake, Gisabella, Barbara, Pantazopoulos, Harry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10311570/
https://www.ncbi.nlm.nih.gov/pubmed/37396928
http://dx.doi.org/10.3389/fncel.2023.1208974
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author Valeri, Jake
Gisabella, Barbara
Pantazopoulos, Harry
author_facet Valeri, Jake
Gisabella, Barbara
Pantazopoulos, Harry
author_sort Valeri, Jake
collection PubMed
description Substance use disorders are a global health problem with increasing prevalence resulting in significant socioeconomic burden and increased mortality. Converging lines of evidence point to a critical role of brain extracellular matrix (ECM) molecules in the pathophysiology of substance use disorders. An increasing number of preclinical studies highlight the ECM as a promising target for development of novel cessation pharmacotherapies. The brain ECM is dynamically regulated during learning and memory processes, thus the time course of ECM alterations in substance use disorders is a critical factor that may impact interpretation of the current studies and development of pharmacological therapies. This review highlights the evidence for the involvement of ECM molecules in reward learning, including drug reward and natural reward such as food, as well as evidence regarding the pathophysiological state of the brain’s ECM in substance use disorders and metabolic disorders. We focus on the information regarding time-course and substance specific changes in ECM molecules and how this information can be leveraged for the development of therapeutic strategies.
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spelling pubmed-103115702023-07-01 Dynamic regulation of the extracellular matrix in reward memory processes: a question of time Valeri, Jake Gisabella, Barbara Pantazopoulos, Harry Front Cell Neurosci Neuroscience Substance use disorders are a global health problem with increasing prevalence resulting in significant socioeconomic burden and increased mortality. Converging lines of evidence point to a critical role of brain extracellular matrix (ECM) molecules in the pathophysiology of substance use disorders. An increasing number of preclinical studies highlight the ECM as a promising target for development of novel cessation pharmacotherapies. The brain ECM is dynamically regulated during learning and memory processes, thus the time course of ECM alterations in substance use disorders is a critical factor that may impact interpretation of the current studies and development of pharmacological therapies. This review highlights the evidence for the involvement of ECM molecules in reward learning, including drug reward and natural reward such as food, as well as evidence regarding the pathophysiological state of the brain’s ECM in substance use disorders and metabolic disorders. We focus on the information regarding time-course and substance specific changes in ECM molecules and how this information can be leveraged for the development of therapeutic strategies. Frontiers Media S.A. 2023-06-16 /pmc/articles/PMC10311570/ /pubmed/37396928 http://dx.doi.org/10.3389/fncel.2023.1208974 Text en Copyright © 2023 Valeri, Gisabella and Pantazopoulos. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Valeri, Jake
Gisabella, Barbara
Pantazopoulos, Harry
Dynamic regulation of the extracellular matrix in reward memory processes: a question of time
title Dynamic regulation of the extracellular matrix in reward memory processes: a question of time
title_full Dynamic regulation of the extracellular matrix in reward memory processes: a question of time
title_fullStr Dynamic regulation of the extracellular matrix in reward memory processes: a question of time
title_full_unstemmed Dynamic regulation of the extracellular matrix in reward memory processes: a question of time
title_short Dynamic regulation of the extracellular matrix in reward memory processes: a question of time
title_sort dynamic regulation of the extracellular matrix in reward memory processes: a question of time
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10311570/
https://www.ncbi.nlm.nih.gov/pubmed/37396928
http://dx.doi.org/10.3389/fncel.2023.1208974
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