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Challenges in Management of Concomitant Primary Aldosteronism and Pheochromocytoma
Patient: Male, 64-year-old Final Diagnosis: Pheochromocytoma • primary aldosteronism Symptoms: Hypertension Clinical Procedure: — Specialty: Endocrinology and metabolic OBJECTIVE: Rare coexistence of disease or pathology BACKGROUND: Primary aldosteronism and pheochromocytoma are endocrine causes of...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Scientific Literature, Inc.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10311573/ https://www.ncbi.nlm.nih.gov/pubmed/37365779 http://dx.doi.org/10.12659/AJCR.939659 |
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author | Veríssimo, David Vinhais, Joana Ivo, Catarina Rodrigues Sousa, Isabel Martins, Ana Cláudia Silva, João Nunes e Lopes, Luís Passos, Dolores de Castro, João Jácome Marcelino, Mafalda |
author_facet | Veríssimo, David Vinhais, Joana Ivo, Catarina Rodrigues Sousa, Isabel Martins, Ana Cláudia Silva, João Nunes e Lopes, Luís Passos, Dolores de Castro, João Jácome Marcelino, Mafalda |
author_sort | Veríssimo, David |
collection | PubMed |
description | Patient: Male, 64-year-old Final Diagnosis: Pheochromocytoma • primary aldosteronism Symptoms: Hypertension Clinical Procedure: — Specialty: Endocrinology and metabolic OBJECTIVE: Rare coexistence of disease or pathology BACKGROUND: Primary aldosteronism and pheochromocytoma are endocrine causes of secondary arterial hypertension. The association of primary aldosteronism and pheochromocytoma is rare and the involved mechanisms are poorly understood. Either there is a coexistence of both diseases or the pheochromocytoma stimulates the production of aldosterone. Since management approaches may differ significantly, it is important to properly diagnose the 2 conditions. We describe concomitant pheochromocytoma and primary aldosteronism in a patient with resistant hypertension, which demanded a challenging and individualized approach. CASE REPORT: A 64-year-old man was sent for observation in our department for type 2 diabetes and resistant hypertension. Laboratory work-up suggested a primary aldosteronism and a pheochromocytoma. The abdominal CT (before and after intravenous contrast, with portal and delayed phase acquisitions) revealed an indeterminate right adrenal lesion and 3 nodules in the left adrenal gland: 1 indeterminate and 2 compatible with adenomas. A 18F-FDOPA PET-CT showed increased uptake in the right adrenal gland. The patient underwent a right adrenalectomy and a pheochromocytoma was confirmed. An improvement in glycemic control was observed after surgery but the patient remained hypertensive. A captopril test confirmed the persistence of primary aldosteronism, and he was started on eplerenone, achieving blood pressure control. CONCLUSIONS: This case highlights the challenges in diagnosing and treating the simultaneous occurrence of pheochromocytoma and primary aldosteronism. Our main goal was surgical removal of the pheochromocytoma due to the risk of an adrenergic crisis. |
format | Online Article Text |
id | pubmed-10311573 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | International Scientific Literature, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-103115732023-07-01 Challenges in Management of Concomitant Primary Aldosteronism and Pheochromocytoma Veríssimo, David Vinhais, Joana Ivo, Catarina Rodrigues Sousa, Isabel Martins, Ana Cláudia Silva, João Nunes e Lopes, Luís Passos, Dolores de Castro, João Jácome Marcelino, Mafalda Am J Case Rep Articles Patient: Male, 64-year-old Final Diagnosis: Pheochromocytoma • primary aldosteronism Symptoms: Hypertension Clinical Procedure: — Specialty: Endocrinology and metabolic OBJECTIVE: Rare coexistence of disease or pathology BACKGROUND: Primary aldosteronism and pheochromocytoma are endocrine causes of secondary arterial hypertension. The association of primary aldosteronism and pheochromocytoma is rare and the involved mechanisms are poorly understood. Either there is a coexistence of both diseases or the pheochromocytoma stimulates the production of aldosterone. Since management approaches may differ significantly, it is important to properly diagnose the 2 conditions. We describe concomitant pheochromocytoma and primary aldosteronism in a patient with resistant hypertension, which demanded a challenging and individualized approach. CASE REPORT: A 64-year-old man was sent for observation in our department for type 2 diabetes and resistant hypertension. Laboratory work-up suggested a primary aldosteronism and a pheochromocytoma. The abdominal CT (before and after intravenous contrast, with portal and delayed phase acquisitions) revealed an indeterminate right adrenal lesion and 3 nodules in the left adrenal gland: 1 indeterminate and 2 compatible with adenomas. A 18F-FDOPA PET-CT showed increased uptake in the right adrenal gland. The patient underwent a right adrenalectomy and a pheochromocytoma was confirmed. An improvement in glycemic control was observed after surgery but the patient remained hypertensive. A captopril test confirmed the persistence of primary aldosteronism, and he was started on eplerenone, achieving blood pressure control. CONCLUSIONS: This case highlights the challenges in diagnosing and treating the simultaneous occurrence of pheochromocytoma and primary aldosteronism. Our main goal was surgical removal of the pheochromocytoma due to the risk of an adrenergic crisis. International Scientific Literature, Inc. 2023-06-27 /pmc/articles/PMC10311573/ /pubmed/37365779 http://dx.doi.org/10.12659/AJCR.939659 Text en © Am J Case Rep, 2023 https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) ) |
spellingShingle | Articles Veríssimo, David Vinhais, Joana Ivo, Catarina Rodrigues Sousa, Isabel Martins, Ana Cláudia Silva, João Nunes e Lopes, Luís Passos, Dolores de Castro, João Jácome Marcelino, Mafalda Challenges in Management of Concomitant Primary Aldosteronism and Pheochromocytoma |
title | Challenges in Management of Concomitant Primary Aldosteronism and Pheochromocytoma |
title_full | Challenges in Management of Concomitant Primary Aldosteronism and Pheochromocytoma |
title_fullStr | Challenges in Management of Concomitant Primary Aldosteronism and Pheochromocytoma |
title_full_unstemmed | Challenges in Management of Concomitant Primary Aldosteronism and Pheochromocytoma |
title_short | Challenges in Management of Concomitant Primary Aldosteronism and Pheochromocytoma |
title_sort | challenges in management of concomitant primary aldosteronism and pheochromocytoma |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10311573/ https://www.ncbi.nlm.nih.gov/pubmed/37365779 http://dx.doi.org/10.12659/AJCR.939659 |
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