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Correlating the Structure and Gene Silencing Activity of Oligonucleotide-Loaded Lipid Nanoparticles Using Small-Angle X-ray Scattering

[Image: see text] With three FDA-approved products, lipid nanoparticles (LNPs) are under intensive development for delivering wide-ranging nucleic acid therapeutics. A significant challenge for LNP development is insufficient understanding of structure–activity relationship (SAR). Small changes in c...

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Detalles Bibliográficos
Autores principales:	Hammel, Michal, Fan, Yuchen, Sarode, Apoorva, Byrnes, Amy E., Zang, Nanzhi, Kou, Ponien, Nagapudi, Karthik, Leung, Dennis, Hoogenraad, Casper C., Chen, Tao, Yen, Chun-Wan, Hura, Greg L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2023
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10311593/ https://www.ncbi.nlm.nih.gov/pubmed/37279108 http://dx.doi.org/10.1021/acsnano.3c01186

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