Epitope-Directed Antibody Elicitation by Genetically Encoded Chemical Cross-Linking Reactivity in the Antigen

[Image: see text] No current methods can selectively elicit an antibody response to a specific conformational epitope in a whole antigen in vivo. Here, we incorporated Nε-acryloyl-l-lysine (AcrK) or Nε-crotonyl-l-lysine (Kcr) with cross-linking activities into the specific epitopes of antigens and i...

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Detalles Bibliográficos
Autores principales: Zhu, Chaoyang, Xu, Liang, Chen, Longxin, Zhang, Zihan, Zhang, Yuhan, Wu, Weiping, Li, Chengxiang, Liu, Shuang, Xiang, Shuqin, Dai, Shengwang, Zhang, Jay, Guo, Hui, Zhou, Yinjian, Wang, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10311653/
https://www.ncbi.nlm.nih.gov/pubmed/37396855
http://dx.doi.org/10.1021/acscentsci.3c00265

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