In Silico Discovery of 5′-Modified 7-Deoxy-7-ethynyl-4′-thioadenosine as a HASPIN Inhibitor and Its Synergistic Anticancer Effect with the PLK1 Inhibitor

[Image: see text] Despite genetic perturbations resulting in embryo lethality for most mitotic kinases, loss of the histone H3 mitotic kinase HASPIN reveals no adverse effect in mice models, establishing HASPIN as a promising target for anticancer therapy. However, developing a HASPIN inhibitor from...

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Detalles Bibliográficos
Autores principales: Kwon, Eun-Ji, Mashelkar, Karishma K., Seo, Juhee, Shin, Yoon-Ze, Sung, Kisu, Jang, Sung Chul, Cheon, Sang Won, Lee, Haeseung, Lee, Hyuk Woo, Kim, Gyudong, Han, Byung Woo, Lee, Sang Kook, Jeong, Lak Shin, Cha, Hyuk-Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10311661/
https://www.ncbi.nlm.nih.gov/pubmed/37396870
http://dx.doi.org/10.1021/acscentsci.3c00332

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