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Investigating association between inflammatory bowel disease and rotavirus vaccination in a paediatric cohort in the UK

In the UK, the incidence and prevalence of inflammatory bowel disease (IBD) is increasing in paediatric populations. Environmental factors including acute gastroenteritis episodes (AGE) may impact IBD development. Infant rotavirus vaccination has been shown to significantly reduce AGE. This study ai...

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Autores principales: Flatt, Aidan, Inns, Thomas, Fleming, Kate M., Iturriza-Gómara, Miren, Hungerford, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10311680/
https://www.ncbi.nlm.nih.gov/pubmed/37293971
http://dx.doi.org/10.1017/S0950268823000936
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author Flatt, Aidan
Inns, Thomas
Fleming, Kate M.
Iturriza-Gómara, Miren
Hungerford, Daniel
author_facet Flatt, Aidan
Inns, Thomas
Fleming, Kate M.
Iturriza-Gómara, Miren
Hungerford, Daniel
author_sort Flatt, Aidan
collection PubMed
description In the UK, the incidence and prevalence of inflammatory bowel disease (IBD) is increasing in paediatric populations. Environmental factors including acute gastroenteritis episodes (AGE) may impact IBD development. Infant rotavirus vaccination has been shown to significantly reduce AGE. This study aims to explore the association between vaccination with live oral rotavirus vaccines and IBD development. A population-based cohort study was used, analysing primary care data from the Clinical Practice Research Datalink Aurum. Participants included children born in the UK from 2010 to 2015, followed from a minimum of 6 months old to a maximum of 7 years old. The primary outcome was IBD, and the primary exposure was rotavirus vaccination. Cox regression analysis with random intercepts for general practices was undertaken, with adjustment for potential confounding factors. In a cohort of 907,477 children, IBD was recorded for 96 participants with an incidence rate of 2.1 per 100,000 person-years at risk. The univariable analysis hazard ratio (HR) for rotavirus vaccination was 1.45 (95% confidence interval (CI) 0.93–2.28). Adjustment in the multivariable model attenuated the HR to 1.19 (95% CI 0.53–2.69). This study shows no statistically significant association between rotavirus vaccination and development of IBD. However, it provides further evidence for the safety of live rotavirus vaccination.
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spelling pubmed-103116802023-07-01 Investigating association between inflammatory bowel disease and rotavirus vaccination in a paediatric cohort in the UK Flatt, Aidan Inns, Thomas Fleming, Kate M. Iturriza-Gómara, Miren Hungerford, Daniel Epidemiol Infect Original Paper In the UK, the incidence and prevalence of inflammatory bowel disease (IBD) is increasing in paediatric populations. Environmental factors including acute gastroenteritis episodes (AGE) may impact IBD development. Infant rotavirus vaccination has been shown to significantly reduce AGE. This study aims to explore the association between vaccination with live oral rotavirus vaccines and IBD development. A population-based cohort study was used, analysing primary care data from the Clinical Practice Research Datalink Aurum. Participants included children born in the UK from 2010 to 2015, followed from a minimum of 6 months old to a maximum of 7 years old. The primary outcome was IBD, and the primary exposure was rotavirus vaccination. Cox regression analysis with random intercepts for general practices was undertaken, with adjustment for potential confounding factors. In a cohort of 907,477 children, IBD was recorded for 96 participants with an incidence rate of 2.1 per 100,000 person-years at risk. The univariable analysis hazard ratio (HR) for rotavirus vaccination was 1.45 (95% confidence interval (CI) 0.93–2.28). Adjustment in the multivariable model attenuated the HR to 1.19 (95% CI 0.53–2.69). This study shows no statistically significant association between rotavirus vaccination and development of IBD. However, it provides further evidence for the safety of live rotavirus vaccination. Cambridge University Press 2023-06-09 /pmc/articles/PMC10311680/ /pubmed/37293971 http://dx.doi.org/10.1017/S0950268823000936 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.
spellingShingle Original Paper
Flatt, Aidan
Inns, Thomas
Fleming, Kate M.
Iturriza-Gómara, Miren
Hungerford, Daniel
Investigating association between inflammatory bowel disease and rotavirus vaccination in a paediatric cohort in the UK
title Investigating association between inflammatory bowel disease and rotavirus vaccination in a paediatric cohort in the UK
title_full Investigating association between inflammatory bowel disease and rotavirus vaccination in a paediatric cohort in the UK
title_fullStr Investigating association between inflammatory bowel disease and rotavirus vaccination in a paediatric cohort in the UK
title_full_unstemmed Investigating association between inflammatory bowel disease and rotavirus vaccination in a paediatric cohort in the UK
title_short Investigating association between inflammatory bowel disease and rotavirus vaccination in a paediatric cohort in the UK
title_sort investigating association between inflammatory bowel disease and rotavirus vaccination in a paediatric cohort in the uk
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10311680/
https://www.ncbi.nlm.nih.gov/pubmed/37293971
http://dx.doi.org/10.1017/S0950268823000936
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