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Investigating association between inflammatory bowel disease and rotavirus vaccination in a paediatric cohort in the UK
In the UK, the incidence and prevalence of inflammatory bowel disease (IBD) is increasing in paediatric populations. Environmental factors including acute gastroenteritis episodes (AGE) may impact IBD development. Infant rotavirus vaccination has been shown to significantly reduce AGE. This study ai...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cambridge University Press
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10311680/ https://www.ncbi.nlm.nih.gov/pubmed/37293971 http://dx.doi.org/10.1017/S0950268823000936 |
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author | Flatt, Aidan Inns, Thomas Fleming, Kate M. Iturriza-Gómara, Miren Hungerford, Daniel |
author_facet | Flatt, Aidan Inns, Thomas Fleming, Kate M. Iturriza-Gómara, Miren Hungerford, Daniel |
author_sort | Flatt, Aidan |
collection | PubMed |
description | In the UK, the incidence and prevalence of inflammatory bowel disease (IBD) is increasing in paediatric populations. Environmental factors including acute gastroenteritis episodes (AGE) may impact IBD development. Infant rotavirus vaccination has been shown to significantly reduce AGE. This study aims to explore the association between vaccination with live oral rotavirus vaccines and IBD development. A population-based cohort study was used, analysing primary care data from the Clinical Practice Research Datalink Aurum. Participants included children born in the UK from 2010 to 2015, followed from a minimum of 6 months old to a maximum of 7 years old. The primary outcome was IBD, and the primary exposure was rotavirus vaccination. Cox regression analysis with random intercepts for general practices was undertaken, with adjustment for potential confounding factors. In a cohort of 907,477 children, IBD was recorded for 96 participants with an incidence rate of 2.1 per 100,000 person-years at risk. The univariable analysis hazard ratio (HR) for rotavirus vaccination was 1.45 (95% confidence interval (CI) 0.93–2.28). Adjustment in the multivariable model attenuated the HR to 1.19 (95% CI 0.53–2.69). This study shows no statistically significant association between rotavirus vaccination and development of IBD. However, it provides further evidence for the safety of live rotavirus vaccination. |
format | Online Article Text |
id | pubmed-10311680 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Cambridge University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-103116802023-07-01 Investigating association between inflammatory bowel disease and rotavirus vaccination in a paediatric cohort in the UK Flatt, Aidan Inns, Thomas Fleming, Kate M. Iturriza-Gómara, Miren Hungerford, Daniel Epidemiol Infect Original Paper In the UK, the incidence and prevalence of inflammatory bowel disease (IBD) is increasing in paediatric populations. Environmental factors including acute gastroenteritis episodes (AGE) may impact IBD development. Infant rotavirus vaccination has been shown to significantly reduce AGE. This study aims to explore the association between vaccination with live oral rotavirus vaccines and IBD development. A population-based cohort study was used, analysing primary care data from the Clinical Practice Research Datalink Aurum. Participants included children born in the UK from 2010 to 2015, followed from a minimum of 6 months old to a maximum of 7 years old. The primary outcome was IBD, and the primary exposure was rotavirus vaccination. Cox regression analysis with random intercepts for general practices was undertaken, with adjustment for potential confounding factors. In a cohort of 907,477 children, IBD was recorded for 96 participants with an incidence rate of 2.1 per 100,000 person-years at risk. The univariable analysis hazard ratio (HR) for rotavirus vaccination was 1.45 (95% confidence interval (CI) 0.93–2.28). Adjustment in the multivariable model attenuated the HR to 1.19 (95% CI 0.53–2.69). This study shows no statistically significant association between rotavirus vaccination and development of IBD. However, it provides further evidence for the safety of live rotavirus vaccination. Cambridge University Press 2023-06-09 /pmc/articles/PMC10311680/ /pubmed/37293971 http://dx.doi.org/10.1017/S0950268823000936 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited. |
spellingShingle | Original Paper Flatt, Aidan Inns, Thomas Fleming, Kate M. Iturriza-Gómara, Miren Hungerford, Daniel Investigating association between inflammatory bowel disease and rotavirus vaccination in a paediatric cohort in the UK |
title | Investigating association between inflammatory bowel disease and rotavirus vaccination in a paediatric cohort in the UK |
title_full | Investigating association between inflammatory bowel disease and rotavirus vaccination in a paediatric cohort in the UK |
title_fullStr | Investigating association between inflammatory bowel disease and rotavirus vaccination in a paediatric cohort in the UK |
title_full_unstemmed | Investigating association between inflammatory bowel disease and rotavirus vaccination in a paediatric cohort in the UK |
title_short | Investigating association between inflammatory bowel disease and rotavirus vaccination in a paediatric cohort in the UK |
title_sort | investigating association between inflammatory bowel disease and rotavirus vaccination in a paediatric cohort in the uk |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10311680/ https://www.ncbi.nlm.nih.gov/pubmed/37293971 http://dx.doi.org/10.1017/S0950268823000936 |
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