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Genetic and epidemiological analyses of infection load and its relationship with psychiatric disorders
Severe infections and psychiatric disorders have a large impact on both society and the individual. Studies investigating these conditions and the links between them are therefore important. Most past studies have focused on binary phenotypes of particular infections or overall infection, thereby lo...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cambridge University Press
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10311684/ https://www.ncbi.nlm.nih.gov/pubmed/37197974 http://dx.doi.org/10.1017/S0950268823000687 |
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author | Nudel, Ron Hougaard, David M. Werge, Thomas Benros, Michael E. |
author_facet | Nudel, Ron Hougaard, David M. Werge, Thomas Benros, Michael E. |
author_sort | Nudel, Ron |
collection | PubMed |
description | Severe infections and psychiatric disorders have a large impact on both society and the individual. Studies investigating these conditions and the links between them are therefore important. Most past studies have focused on binary phenotypes of particular infections or overall infection, thereby losing some information regarding susceptibility to infection as reflected in the number of specific infection types, or sites, which we term infection load. In this study we found that infection load was associated with increased risk for attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, depression, schizophrenia and overall psychiatric diagnosis. We obtained a modest but significant heritability for infection load (h(2) = 0.0221), and a high degree of genetic correlation between it and overall psychiatric diagnosis (r(g) = 0.4298). We also found evidence supporting a genetic causality for overall infection on overall psychiatric diagnosis. Our genome-wide association study for infection load identified 138 suggestive associations. Our study provides further evidence for genetic links between susceptibility to infection and psychiatric disorders, and suggests that a higher infection load may have a cumulative association with psychiatric disorders, beyond what has been described for individual infections. |
format | Online Article Text |
id | pubmed-10311684 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Cambridge University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-103116842023-07-01 Genetic and epidemiological analyses of infection load and its relationship with psychiatric disorders Nudel, Ron Hougaard, David M. Werge, Thomas Benros, Michael E. Epidemiol Infect Original Paper Severe infections and psychiatric disorders have a large impact on both society and the individual. Studies investigating these conditions and the links between them are therefore important. Most past studies have focused on binary phenotypes of particular infections or overall infection, thereby losing some information regarding susceptibility to infection as reflected in the number of specific infection types, or sites, which we term infection load. In this study we found that infection load was associated with increased risk for attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, depression, schizophrenia and overall psychiatric diagnosis. We obtained a modest but significant heritability for infection load (h(2) = 0.0221), and a high degree of genetic correlation between it and overall psychiatric diagnosis (r(g) = 0.4298). We also found evidence supporting a genetic causality for overall infection on overall psychiatric diagnosis. Our genome-wide association study for infection load identified 138 suggestive associations. Our study provides further evidence for genetic links between susceptibility to infection and psychiatric disorders, and suggests that a higher infection load may have a cumulative association with psychiatric disorders, beyond what has been described for individual infections. Cambridge University Press 2023-05-18 /pmc/articles/PMC10311684/ /pubmed/37197974 http://dx.doi.org/10.1017/S0950268823000687 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited. |
spellingShingle | Original Paper Nudel, Ron Hougaard, David M. Werge, Thomas Benros, Michael E. Genetic and epidemiological analyses of infection load and its relationship with psychiatric disorders |
title | Genetic and epidemiological analyses of infection load and its relationship with psychiatric disorders |
title_full | Genetic and epidemiological analyses of infection load and its relationship with psychiatric disorders |
title_fullStr | Genetic and epidemiological analyses of infection load and its relationship with psychiatric disorders |
title_full_unstemmed | Genetic and epidemiological analyses of infection load and its relationship with psychiatric disorders |
title_short | Genetic and epidemiological analyses of infection load and its relationship with psychiatric disorders |
title_sort | genetic and epidemiological analyses of infection load and its relationship with psychiatric disorders |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10311684/ https://www.ncbi.nlm.nih.gov/pubmed/37197974 http://dx.doi.org/10.1017/S0950268823000687 |
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