Single-cell transcriptomics reveals cellular heterogeneity and macrophage-to-mesenchymal transition in bicuspid calcific aortic valve disease

BACKGROUND: Bicuspid aortic valve (BAV) is the most prevalent congenital valvular heart defect, and around 50% of severe isolated calcific aortic valve disease (CAVD) cases are associated with BAV. Although previous studies have demonstrated the cellular heterogeneity of aortic valves, the cellular...

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Detalles Bibliográficos
Autores principales: Lyu, Tao, Liu, Yang, Li, Binglin, Xu, Ran, Guo, Jianghong, Zhu, Dan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10311753/
https://www.ncbi.nlm.nih.gov/pubmed/37391760
http://dx.doi.org/10.1186/s13062-023-00390-w

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