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Decreased level of serum NT-proCNP associates with disease severity in COVID-19

BACKGROUND: C-type natriuretic peptide (CNP) is an endothelium-derived paracrine molecule with an important role in vascular homeostasis. In septic patients, the serum level of the amino-terminal propeptide of CNP (NT-proCNP) shows a strong positive correlation with inflammatory biomarkers and, if e...

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Autores principales: Bojti, Istvan, Przewosnik, Anne-Sophie, Luxenburger, Hendrik, Hofmann, Maike, Neumann-Haefelin, Christoph, Esser, Jennifer S., Siegel, Patrick M., Maier, Alexander, Kovacs, Sarolta Bojtine, Kardos, Laszlo, Csanádi, Zoltan, Rieder, Marina, Duerschmied, Daniel, Lother, Achim, Bode, Christoph, Szabó, Gabor Tamas, Czuriga, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10311835/
https://www.ncbi.nlm.nih.gov/pubmed/37386635
http://dx.doi.org/10.1186/s12931-023-02469-4
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author Bojti, Istvan
Przewosnik, Anne-Sophie
Luxenburger, Hendrik
Hofmann, Maike
Neumann-Haefelin, Christoph
Esser, Jennifer S.
Siegel, Patrick M.
Maier, Alexander
Kovacs, Sarolta Bojtine
Kardos, Laszlo
Csanádi, Zoltan
Rieder, Marina
Duerschmied, Daniel
Lother, Achim
Bode, Christoph
Szabó, Gabor Tamas
Czuriga, Daniel
author_facet Bojti, Istvan
Przewosnik, Anne-Sophie
Luxenburger, Hendrik
Hofmann, Maike
Neumann-Haefelin, Christoph
Esser, Jennifer S.
Siegel, Patrick M.
Maier, Alexander
Kovacs, Sarolta Bojtine
Kardos, Laszlo
Csanádi, Zoltan
Rieder, Marina
Duerschmied, Daniel
Lother, Achim
Bode, Christoph
Szabó, Gabor Tamas
Czuriga, Daniel
author_sort Bojti, Istvan
collection PubMed
description BACKGROUND: C-type natriuretic peptide (CNP) is an endothelium-derived paracrine molecule with an important role in vascular homeostasis. In septic patients, the serum level of the amino-terminal propeptide of CNP (NT-proCNP) shows a strong positive correlation with inflammatory biomarkers and, if elevated, correlates with disease severity and indicates a poor outcome. It is not yet known whether NT-proCNP also correlates with the clinical outcome of patients suffering from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. In the current study, we aimed to determine possible changes in the NT-proCNP levels of patients with coronavirus disease 2019 (COVID-19), with special regard to disease severity and outcome. METHODS: In this retrospective analysis, we determined the serum level of NT-proCNP in hospitalized patients with symptoms of upper respiratory tract infection, using their blood samples taken on admission, stored in a biobank. The NT-proCNP levels of 32 SARS-CoV-2 positive and 35 SARS-CoV-2 negative patients were measured to investigate possible correlation with disease outcome. SARS-CoV-2 positive patients were then divided into two groups based on their need for intensive care unit treatment (severe and mild COVID-19). RESULTS: The NT-proCNP was significantly different in the study groups (e.g. severe and mild COVID-19 and non-COVID-19 patients), but showed inverse changes compared to previous observations in septic patients: lowest levels were detected in critically ill COVID-19 patients, while highest levels in the non-COVID-19 group. A low level of NT-proCNP on admission was significantly associated with severe disease outcome. CONCLUSIONS: Low-level NT-proCNP on hospital admission is associated with a severe COVID-19 disease course. The pathomechanism underlying this observation remains to be elucidated, while future studies in larger patient cohorts are necessary to confirm these observations and reveal therapeutic importance. Trial registration DRKS00026655 Registered 26. November 2021 SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12931-023-02469-4.
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spelling pubmed-103118352023-07-01 Decreased level of serum NT-proCNP associates with disease severity in COVID-19 Bojti, Istvan Przewosnik, Anne-Sophie Luxenburger, Hendrik Hofmann, Maike Neumann-Haefelin, Christoph Esser, Jennifer S. Siegel, Patrick M. Maier, Alexander Kovacs, Sarolta Bojtine Kardos, Laszlo Csanádi, Zoltan Rieder, Marina Duerschmied, Daniel Lother, Achim Bode, Christoph Szabó, Gabor Tamas Czuriga, Daniel Respir Res Research BACKGROUND: C-type natriuretic peptide (CNP) is an endothelium-derived paracrine molecule with an important role in vascular homeostasis. In septic patients, the serum level of the amino-terminal propeptide of CNP (NT-proCNP) shows a strong positive correlation with inflammatory biomarkers and, if elevated, correlates with disease severity and indicates a poor outcome. It is not yet known whether NT-proCNP also correlates with the clinical outcome of patients suffering from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. In the current study, we aimed to determine possible changes in the NT-proCNP levels of patients with coronavirus disease 2019 (COVID-19), with special regard to disease severity and outcome. METHODS: In this retrospective analysis, we determined the serum level of NT-proCNP in hospitalized patients with symptoms of upper respiratory tract infection, using their blood samples taken on admission, stored in a biobank. The NT-proCNP levels of 32 SARS-CoV-2 positive and 35 SARS-CoV-2 negative patients were measured to investigate possible correlation with disease outcome. SARS-CoV-2 positive patients were then divided into two groups based on their need for intensive care unit treatment (severe and mild COVID-19). RESULTS: The NT-proCNP was significantly different in the study groups (e.g. severe and mild COVID-19 and non-COVID-19 patients), but showed inverse changes compared to previous observations in septic patients: lowest levels were detected in critically ill COVID-19 patients, while highest levels in the non-COVID-19 group. A low level of NT-proCNP on admission was significantly associated with severe disease outcome. CONCLUSIONS: Low-level NT-proCNP on hospital admission is associated with a severe COVID-19 disease course. The pathomechanism underlying this observation remains to be elucidated, while future studies in larger patient cohorts are necessary to confirm these observations and reveal therapeutic importance. Trial registration DRKS00026655 Registered 26. November 2021 SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12931-023-02469-4. BioMed Central 2023-06-29 2023 /pmc/articles/PMC10311835/ /pubmed/37386635 http://dx.doi.org/10.1186/s12931-023-02469-4 Text en © The Author(s) 2023, Corrected publication 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Bojti, Istvan
Przewosnik, Anne-Sophie
Luxenburger, Hendrik
Hofmann, Maike
Neumann-Haefelin, Christoph
Esser, Jennifer S.
Siegel, Patrick M.
Maier, Alexander
Kovacs, Sarolta Bojtine
Kardos, Laszlo
Csanádi, Zoltan
Rieder, Marina
Duerschmied, Daniel
Lother, Achim
Bode, Christoph
Szabó, Gabor Tamas
Czuriga, Daniel
Decreased level of serum NT-proCNP associates with disease severity in COVID-19
title Decreased level of serum NT-proCNP associates with disease severity in COVID-19
title_full Decreased level of serum NT-proCNP associates with disease severity in COVID-19
title_fullStr Decreased level of serum NT-proCNP associates with disease severity in COVID-19
title_full_unstemmed Decreased level of serum NT-proCNP associates with disease severity in COVID-19
title_short Decreased level of serum NT-proCNP associates with disease severity in COVID-19
title_sort decreased level of serum nt-procnp associates with disease severity in covid-19
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10311835/
https://www.ncbi.nlm.nih.gov/pubmed/37386635
http://dx.doi.org/10.1186/s12931-023-02469-4
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