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Social visual preference mediates the effect of cortical thickness on symptom severity in children with autism spectrum disorder

BACKGROUND: Evidence suggests that there is a robust relationship between altered neuroanatomy and autistic symptoms in individuals with autism spectrum disorder (ASD). Social visual preference, which is regulated by specific brain regions, is also related to symptom severity. However, there were a...

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Autores principales: Chen, Jierong, Wei, Zhen, Xu, Chuangyong, Peng, Ziwen, Yang, Junjie, Wan, Guobin, Chen, Bin, Gong, Jianhua, Zhou, Keying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10311909/
https://www.ncbi.nlm.nih.gov/pubmed/37398604
http://dx.doi.org/10.3389/fpsyt.2023.1132284
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author Chen, Jierong
Wei, Zhen
Xu, Chuangyong
Peng, Ziwen
Yang, Junjie
Wan, Guobin
Chen, Bin
Gong, Jianhua
Zhou, Keying
author_facet Chen, Jierong
Wei, Zhen
Xu, Chuangyong
Peng, Ziwen
Yang, Junjie
Wan, Guobin
Chen, Bin
Gong, Jianhua
Zhou, Keying
author_sort Chen, Jierong
collection PubMed
description BACKGROUND: Evidence suggests that there is a robust relationship between altered neuroanatomy and autistic symptoms in individuals with autism spectrum disorder (ASD). Social visual preference, which is regulated by specific brain regions, is also related to symptom severity. However, there were a few studies explored the potential relationships among brain structure, symptom severity, and social visual preference. METHODS: The current study investigated relationships among brain structure, social visual preference, and symptom severity in 43 children with ASD and 26 typically developing (TD) children (aged 2–6 years). RESULTS: Significant differences were found in social visual preference and cortical morphometry between the two groups. Decreased percentage of fixation time in digital social images (%DSI) was negatively related to not only the thickness of the left fusiform gyrus (FG) and right insula, but also the Calibrated Severity Scores for the Autism Diagnostic Observation Schedule-Social Affect (ADOS-SA-CSS). Mediation analysis showed that %DSI partially mediated the relationship between neuroanatomical alterations (specifically, thickness of the left FG and right insula) and symptom severity. CONCLUSION: These findings offer initial evidence that atypical neuroanatomical alterations may not only result in direct effects on symptom severity but also lead to indirect effects on symptom severity through social visual preference. This finding enhances our understanding of the multiple neural mechanisms implicated in ASD.
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spelling pubmed-103119092023-07-01 Social visual preference mediates the effect of cortical thickness on symptom severity in children with autism spectrum disorder Chen, Jierong Wei, Zhen Xu, Chuangyong Peng, Ziwen Yang, Junjie Wan, Guobin Chen, Bin Gong, Jianhua Zhou, Keying Front Psychiatry Psychiatry BACKGROUND: Evidence suggests that there is a robust relationship between altered neuroanatomy and autistic symptoms in individuals with autism spectrum disorder (ASD). Social visual preference, which is regulated by specific brain regions, is also related to symptom severity. However, there were a few studies explored the potential relationships among brain structure, symptom severity, and social visual preference. METHODS: The current study investigated relationships among brain structure, social visual preference, and symptom severity in 43 children with ASD and 26 typically developing (TD) children (aged 2–6 years). RESULTS: Significant differences were found in social visual preference and cortical morphometry between the two groups. Decreased percentage of fixation time in digital social images (%DSI) was negatively related to not only the thickness of the left fusiform gyrus (FG) and right insula, but also the Calibrated Severity Scores for the Autism Diagnostic Observation Schedule-Social Affect (ADOS-SA-CSS). Mediation analysis showed that %DSI partially mediated the relationship between neuroanatomical alterations (specifically, thickness of the left FG and right insula) and symptom severity. CONCLUSION: These findings offer initial evidence that atypical neuroanatomical alterations may not only result in direct effects on symptom severity but also lead to indirect effects on symptom severity through social visual preference. This finding enhances our understanding of the multiple neural mechanisms implicated in ASD. Frontiers Media S.A. 2023-06-16 /pmc/articles/PMC10311909/ /pubmed/37398604 http://dx.doi.org/10.3389/fpsyt.2023.1132284 Text en Copyright © 2023 Chen, Wei, Xu, Peng, Yang, Wan, Chen, Gong and Zhou. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Chen, Jierong
Wei, Zhen
Xu, Chuangyong
Peng, Ziwen
Yang, Junjie
Wan, Guobin
Chen, Bin
Gong, Jianhua
Zhou, Keying
Social visual preference mediates the effect of cortical thickness on symptom severity in children with autism spectrum disorder
title Social visual preference mediates the effect of cortical thickness on symptom severity in children with autism spectrum disorder
title_full Social visual preference mediates the effect of cortical thickness on symptom severity in children with autism spectrum disorder
title_fullStr Social visual preference mediates the effect of cortical thickness on symptom severity in children with autism spectrum disorder
title_full_unstemmed Social visual preference mediates the effect of cortical thickness on symptom severity in children with autism spectrum disorder
title_short Social visual preference mediates the effect of cortical thickness on symptom severity in children with autism spectrum disorder
title_sort social visual preference mediates the effect of cortical thickness on symptom severity in children with autism spectrum disorder
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10311909/
https://www.ncbi.nlm.nih.gov/pubmed/37398604
http://dx.doi.org/10.3389/fpsyt.2023.1132284
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