Cargando…

Strategies to reinvigorate exhausted CD8(+) T cells in tumor microenvironment

CD8(+) T cell exhaustion is a stable dysfunctional state driven by chronic antigen stimulation in the tumor microenvironment (TME). Differentiation of exhausted CD8(+) T cells (CD8(+) TEXs) is accompanied by extensive transcriptional, epigenetic and metabolic reprogramming. CD8(+) TEXs are mainly ch...

Descripción completa

Detalles Bibliográficos
Autores principales:	Guan, Qianting, Han, Meiwen, Guo, Qinghao, Yan, Fangfei, Wang, Ming, Ning, Qin, Xi, Dong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10311918/ https://www.ncbi.nlm.nih.gov/pubmed/37398660 http://dx.doi.org/10.3389/fimmu.2023.1204363

Ejemplares similares

T-Cell Exhaustion in Chronic Infections: Reversing the State of Exhaustion and Reinvigorating Optimal Protective Immune Responses
por: Saeidi, Alireza, et al.
Publicado: (2018)

Novel Prognostic Nomogram to Predict Progression-Free Survival of Patients with Hepatocellular Carcinoma After Transarterial Chemoembolization
por: Xi, Dong, et al.
Publicado: (2023)

Exhausted CD8+T Cells in the Tumor Immune Microenvironment: New Pathways to Therapy
por: Jiang, Weiqin, et al.
Publicado: (2021)

PD-1 Immune Checkpoint Blockade and PSGL-1 Inhibition Synergize to Reinvigorate Exhausted T Cells
por: Viramontes, Karla M., et al.
Publicado: (2022)

Exhaust the exhausters: Targeting regulatory T cells in the tumor microenvironment
por: McRitchie, Bayley R., et al.
Publicado: (2022)

NK cell exhaustion in the tumor microenvironment
por: Jia, Hao, et al.
Publicado: (2023)

Targeting Nuclear LSD1 to Reprogram Cancer Cells and Reinvigorate Exhausted T Cells via a Novel LSD1-EOMES Switch
por: Tu, Wen Juan, et al.
Publicado: (2020)

4-1BB co-stimulation further enhances anti-PD-1-mediated reinvigoration of exhausted CD39(+) CD8 T cells from primary and metastatic sites of epithelial ovarian cancers
por: Leem, Galam, et al.
Publicado: (2020)

High Levels of Eomes Promote Exhaustion of Anti-tumor CD8(+) T Cells
por: Li, Jing, et al.
Publicado: (2018)

CD8(+) T Cell Exhaustion in Cancer
por: Dolina, Joseph S., et al.
Publicado: (2021)

Neutrophil Extracellular Traps Promote T Cell Exhaustion in the Tumor Microenvironment
por: Kaltenmeier, Christof, et al.
Publicado: (2021)

EPS reinvigorated
Publicado: (1973)

Dynamic Network Biomarker of Pre-Exhausted CD8(+) T Cells Contributed to T Cell Exhaustion in Colorectal Cancer
por: Hu, Jiaqi, et al.
Publicado: (2021)

Enhanced Phenotype Definition for Precision Isolation of Precursor Exhausted Tumor-Infiltrating CD8 T Cells
por: Martinez-Usatorre, Amaia, et al.
Publicado: (2020)

Helpless Priming Sends CD8(+) T Cells on the Road to Exhaustion
por: Busselaar, Julia, et al.
Publicado: (2020)

Hypoxia Supports Differentiation of Terminally Exhausted CD8 T Cells
por: Bannoud, Nadia, et al.
Publicado: (2021)

Landscapes and mechanisms of CD8(+) T cell exhaustion in gastrointestinal cancer
por: Ding, Jia-Tong, et al.
Publicado: (2023)

Dendritic Cells and CD8 T Cell Immunity in Tumor Microenvironment
por: Fu, Chunmei, et al.
Publicado: (2018)

Fundamentals to therapeutics: Epigenetic modulation of CD8(+) T Cell exhaustion in the tumor microenvironment
por: Blake, Maja K., et al.
Publicado: (2023)

Reinvigorating exhausted HIV-specific T cells via PD-1–PD-1 ligand blockade
por: Freeman, Gordon J., et al.
Publicado: (2006)

The development of CD8 T-cell exhaustion heterogeneity and the therapeutic potentials in cancer
por: Zhang, Junfeng, et al.
Publicado: (2023)

Ibrutinib directly reduces CD8+T cell exhaustion independent of BTK
por: Li, Ling, et al.
Publicado: (2023)

Establishment and validation of exhausted CD8+ T cell feature as a prognostic model of HCC
por: Shi, Jihang, et al.
Publicado: (2023)

Reinvigorating electrochemistry education
por: Kempler, Paul A., et al.
Publicado: (2021)

CAPN8 involves with exhausted, inflamed, and desert immune microenvironment to influence the metastasis of thyroid cancer
por: Zhong, Xiang, et al.
Publicado: (2022)

Modulation of natural killer cell exhaustion in the lungs: the key components from lung microenvironment and lung tumor microenvironment
por: Zhang, Hongxia, et al.
Publicado: (2023)

CD38 marks the exhausted CD8(+) tissue-resident memory T cells in hepatocellular carcinoma
por: Reolo, Marie J. Y., et al.
Publicado: (2023)

High CD8(+)tumor-infiltrating lymphocytes indicate severe exhaustion and poor prognosis in angioimmunoblastic T-cell lymphoma
por: Zhu, Qiqi, et al.
Publicado: (2023)

Epitherapy and immune checkpoint blockade: using epigenetic reinvigoration of exhausted and dysfunctional T cells to reimburse immunotherapy response
por: McGoverne, Isabella, et al.
Publicado: (2020)

Elevated Exhaustion Levels of NK and CD8(+) T Cells as Indicators for Progression and Prognosis of COVID-19 Disease
por: Li, Mingyue, et al.
Publicado: (2020)

Construction and validation of chemoresistance-associated tumor- infiltrating exhausted-like CD8+ T cell signature in breast cancer: cr-TILCD8TSig
por: Cai, DQ., et al.
Publicado: (2023)

Exhaustion of the CD8(+) T Cell Compartment in Patients with Mutations in Phosphoinositide 3-Kinase Delta
por: Wentink, Marjolein W. J., et al.
Publicado: (2018)

The Road Less Taken: Less Appreciated Pathways for Manipulating CD8(+) T Cell Exhaustion
por: Pichler, Andrea C., et al.
Publicado: (2022)

Reinvigorating the Role of Science in Democracy
por: Rosenberg, Andrew A., et al.
Publicado: (2013)

Reinvigorating therapeutic cancer vaccines
por: Robles-Oteiza, Camila, et al.
Publicado: (2022)

Renal Cell Carcinoma (RCC) Tumors Display Large Expansion of Double Positive (DP) CD4+CD8+ T Cells With Expression of Exhaustion Markers
por: Menard, Laurence C., et al.
Publicado: (2018)

Peripheral Autoimmune Regulator Induces Exhaustion of CD4(+) and CD8(+) Effector T Cells to Attenuate Autoimmune Diabetes in Non-Obese Diabetic Mice
por: Kulshrestha, Divakar, et al.
Publicado: (2017)

Hypoxia Induces Mitochondrial Defect That Promotes T Cell Exhaustion in Tumor Microenvironment Through MYC-Regulated Pathways
por: Liu, Yi-Na, et al.
Publicado: (2020)

Microenvironment-Dependent Gradient of CTL Exhaustion in the AE17sOVA Murine Mesothelioma Tumor Model
por: Hope, Jennifer L., et al.
Publicado: (2020)

Regulatory T-cells-related signature for identifying a prognostic subtype of hepatocellular carcinoma with an exhausted tumor microenvironment
por: Zhang, Genhao
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_colr1vvj20artcdrebi4j4d3un