Increase in invasive group A streptococcal infections and emergence of novel, rapidly expanding sub-lineage of the virulent Streptococcus pyogenes M1 clone, Denmark, 2023

A highly virulent sub-lineage of the Streptococcus pyogenes M1 clone has been rapidly expanding throughout Denmark since late 2022 and now accounts for 30% of the new invasive group A streptococcal infections. We aimed to investigate whether a shift in variant composition can account for the high in...

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Detalles Bibliográficos
Autores principales: Johannesen, Thor Bech, Munkstrup, Charlotte, Edslev, Sofie Marie, Baig, Sharmin, Nielsen, Stine, Funk, Tjede, Kristensen, Dennis Karsten, Jacobsen, Lars Hervig, Ravn, Signe Fischer, Bindslev, Niels, Gubbels, Sophie, Voldstedlund, Marianne, Jokelainen, Pikka, Hallstrøm, Søren, Rasmussen, Astrid, Kristinsson, Karl Gústaf, Fuglsang-Damgaard, David, Dessau, Ram B, Olsén, Agnieszka Barbara, Jensen, Christian Salgaard, Skovby, Annette, Ellermann-Eriksen, Svend, Jensen, Thøger Gorm, Dzajic, Esad, Østergaard, Claus, Lomborg Andersen, Steen, Hoffmann, Steen, Andersen, Peter Henrik, Stegger, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Centre for Disease Prevention and Control (ECDC) 2023
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10311951/
https://www.ncbi.nlm.nih.gov/pubmed/37382884
http://dx.doi.org/10.2807/1560-7917.ES.2023.28.26.2300291
Descripción
Sumario:A highly virulent sub-lineage of the Streptococcus pyogenes M1 clone has been rapidly expanding throughout Denmark since late 2022 and now accounts for 30% of the new invasive group A streptococcal infections. We aimed to investigate whether a shift in variant composition can account for the high incidence rates observed over winter 2022/23, or if these are better explained by the impact of COVID-19-related restrictions on population immunity and carriage of group A Streptococcus.

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