Synthesis, antimycobacterial evaluation, and molecular docking study of 1,2,4-triazole derivatives

Fifteen 1,2,4-triazole derivatives were synthesised in this study and their MIC values against Mycobacterium tuberculosis (Mtb) ranged from 2 to 32 μg/mL. Furthermore, their antimycobacterial activity was positively correlated with the KatG enzyme docking score. Among the 15 compounds, compound 4 sh...

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Detalles Bibliográficos
Autores principales: Xia, Meng-Yu, Cai, Yu-Xiang, Chen, Jun-Xian, Zhao, Xin, Dong, Hong-Mei, Yang, Zai-Chang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312031/
https://www.ncbi.nlm.nih.gov/pubmed/37381729
http://dx.doi.org/10.1080/14756366.2023.2229070

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312031/
https://www.ncbi.nlm.nih.gov/pubmed/37381729
http://dx.doi.org/10.1080/14756366.2023.2229070

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