Postsynaptic Protein Shank3a Deficiency Synergizes with Alzheimer's Disease Neuropathology to Impair Cognitive Performance in the 3xTg-AD Murine Model

Synaptic loss is intrinsically linked to Alzheimer's disease (AD) neuropathology and symptoms, but its direct impact on clinical symptoms remains elusive. The postsynaptic protein Shank3 (SH3 and multiple ankyrin repeat domains) is of particular interest, as the loss of a single allele of the S...

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Detalles Bibliográficos
Autores principales: Landry, Olivier, François, Arnaud, Oye Mintsa Mi-Mba, Méryl-Farelle, Traversy, Marie-Therese, Tremblay, Cyntia, Emond, Vincent, Bennett, David A., Gylys, Karen H., Buxbaum, Joseph D., Calon, Frédéric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312061/
https://www.ncbi.nlm.nih.gov/pubmed/37253603
http://dx.doi.org/10.1523/JNEUROSCI.1945-22.2023

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