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Excessively increased thalamocortical connectivity and poor initial antiseizure medication response in epilepsy patients
OBJECTIVES: The network mechanism underlying the initial response to antiseizure medication in epilepsy has not been revealed yet. Given the central role of the thalamus in the brain network, we conducted a case-control study to investigate the association between thalamic connectivity and medicatio...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312096/ https://www.ncbi.nlm.nih.gov/pubmed/37396772 http://dx.doi.org/10.3389/fneur.2023.1153563 |
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author | Zhong, Jiyuan Tan, Ge Wang, Haijiao Chen, Yangmei |
author_facet | Zhong, Jiyuan Tan, Ge Wang, Haijiao Chen, Yangmei |
author_sort | Zhong, Jiyuan |
collection | PubMed |
description | OBJECTIVES: The network mechanism underlying the initial response to antiseizure medication in epilepsy has not been revealed yet. Given the central role of the thalamus in the brain network, we conducted a case-control study to investigate the association between thalamic connectivity and medication response. METHODS: We recruited 39 patients with newly diagnosed and medication-naïve epilepsy of genetic or unknown etiology, including 26 with a good response (GR group) and 13 with a poor response (PR group), and 26 matched healthy participants (control group). We measured the gray matter density (GMD) and the amplitude of low-frequency fluctuation (ALFF) of bilateral thalami. We then set each thalamus as the seed region of interest (ROI) to calculate voxel-wise functional connectivity (FC) and assessed ROI-wise effective connectivity (EC) between the thalamus and targeted regions. RESULTS: We found no significant difference between groups in the GMD or ALFF of bilateral thalami. However, we observed that the FC values of several circuits connecting the left thalamus and the cortical areas, including the bilateral Rolandic operculum, the left insula, the left postcentral gyrus, the left supramarginal gyrus, and the left superior temporal gyrus, differed among groups (False Discovery Rate correction, P < 0.05), with a higher value in the PR group than in the GR group and/or the control group (Bonferroni correction, P < 0.05). Similarly, both the outflow and the inflow EC in each thalamocortical circuit were higher in the PR group than in the GR group and the control group, although these differences did not remain statistically significant after applying the Bonferroni correction (P < 0.05). The FC showed a positive correlation with the corresponding outflow and inflow ECs for each circuit. CONCLUSION: Our finding suggested that patients with stronger thalamocortical connectivity, potentially driven by both thalamic outflowing and inflowing information, may be more likely to respond poorly to initial antiseizure medication. |
format | Online Article Text |
id | pubmed-10312096 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-103120962023-07-01 Excessively increased thalamocortical connectivity and poor initial antiseizure medication response in epilepsy patients Zhong, Jiyuan Tan, Ge Wang, Haijiao Chen, Yangmei Front Neurol Neurology OBJECTIVES: The network mechanism underlying the initial response to antiseizure medication in epilepsy has not been revealed yet. Given the central role of the thalamus in the brain network, we conducted a case-control study to investigate the association between thalamic connectivity and medication response. METHODS: We recruited 39 patients with newly diagnosed and medication-naïve epilepsy of genetic or unknown etiology, including 26 with a good response (GR group) and 13 with a poor response (PR group), and 26 matched healthy participants (control group). We measured the gray matter density (GMD) and the amplitude of low-frequency fluctuation (ALFF) of bilateral thalami. We then set each thalamus as the seed region of interest (ROI) to calculate voxel-wise functional connectivity (FC) and assessed ROI-wise effective connectivity (EC) between the thalamus and targeted regions. RESULTS: We found no significant difference between groups in the GMD or ALFF of bilateral thalami. However, we observed that the FC values of several circuits connecting the left thalamus and the cortical areas, including the bilateral Rolandic operculum, the left insula, the left postcentral gyrus, the left supramarginal gyrus, and the left superior temporal gyrus, differed among groups (False Discovery Rate correction, P < 0.05), with a higher value in the PR group than in the GR group and/or the control group (Bonferroni correction, P < 0.05). Similarly, both the outflow and the inflow EC in each thalamocortical circuit were higher in the PR group than in the GR group and the control group, although these differences did not remain statistically significant after applying the Bonferroni correction (P < 0.05). The FC showed a positive correlation with the corresponding outflow and inflow ECs for each circuit. CONCLUSION: Our finding suggested that patients with stronger thalamocortical connectivity, potentially driven by both thalamic outflowing and inflowing information, may be more likely to respond poorly to initial antiseizure medication. Frontiers Media S.A. 2023-06-16 /pmc/articles/PMC10312096/ /pubmed/37396772 http://dx.doi.org/10.3389/fneur.2023.1153563 Text en Copyright © 2023 Zhong, Tan, Wang and Chen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neurology Zhong, Jiyuan Tan, Ge Wang, Haijiao Chen, Yangmei Excessively increased thalamocortical connectivity and poor initial antiseizure medication response in epilepsy patients |
title | Excessively increased thalamocortical connectivity and poor initial antiseizure medication response in epilepsy patients |
title_full | Excessively increased thalamocortical connectivity and poor initial antiseizure medication response in epilepsy patients |
title_fullStr | Excessively increased thalamocortical connectivity and poor initial antiseizure medication response in epilepsy patients |
title_full_unstemmed | Excessively increased thalamocortical connectivity and poor initial antiseizure medication response in epilepsy patients |
title_short | Excessively increased thalamocortical connectivity and poor initial antiseizure medication response in epilepsy patients |
title_sort | excessively increased thalamocortical connectivity and poor initial antiseizure medication response in epilepsy patients |
topic | Neurology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312096/ https://www.ncbi.nlm.nih.gov/pubmed/37396772 http://dx.doi.org/10.3389/fneur.2023.1153563 |
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