CARD-like domains mediate anti-phage defense in bacterial gasdermin systems

Caspase recruitment domains (CARDs) and pyrin domains are important facilitators of inflammasome activity and pyroptosis. Upon pathogen recognition by NLR proteins, CARDs recruit and activate caspases, which, in turn, activate gasdermin pore forming proteins to and induce pyroptotic cell death. Here...

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Detalles Bibliográficos
Autores principales: Wein, Tanita, Johnson, Alex G., Millman, Adi, Lange, Katharina, Yirmiya, Erez, Hadary, Romi, Garb, Jeremy, Steinruecke, Felix, Hill, Aidan B., Kranzusch, Philip J., Sorek, Rotem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312443/
https://www.ncbi.nlm.nih.gov/pubmed/37398489
http://dx.doi.org/10.1101/2023.05.28.542683

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