Multiplex single-cell chemical genomics reveals the kinase dependence of the response to targeted therapy

Chemical genetic screens are a powerful tool for exploring how cancer cells’ response to drugs is shaped by their mutations, yet they lack a molecular view of the contribution of individual genes to the response to exposure. Here, we present sci-Plex-Gene-by-Environment (sci-Plex-GxE), a platform fo...

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Detalles Bibliográficos
Autores principales: McFaline-Figueroa, José L., Srivatsan, Sanjay, Hill, Andrew J., Gasperini, Molly, Jackson, Dana L., Saunders, Lauren, Domcke, Silvia, Regalado, Samuel G., Lazarchuck, Paul, Alvarez, Sarai, Monnat, Raymond J., Shendure, Jay, Trapnell, Cole
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312454/
https://www.ncbi.nlm.nih.gov/pubmed/37398090
http://dx.doi.org/10.1101/2023.03.10.531983

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