Cargando…

Mapping the genomic landscape of multidrug resistance in Plasmodium falciparum and its impact on parasite fitness

Mostrar otras versiones (1)

Drug-resistant Plasmodium falciparum parasites have swept across Southeast Asia and now threaten Africa. By implementing a P. falciparum genetic cross using humanized mice, we report the identification of key determinants of resistance to artemisinin (ART) and piperaquine (PPQ) in the dominant Asian...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mok, Sachel, Yeo, Tomas, Hong, Davin, Shears, Melanie J., Ross, Leila S., Ward, Kurt E., Dhingra, Satish K., Kanai, Mariko, Bridgford, Jessica L., Tripathi, Abhai K., Mlambo, Godfree, Burkhard, Anna Y., Fairhurst, Kate J., Gil-Iturbe, Eva, Park, Heekuk, Rozenberg, Felix D., Kim, Jonathan, Mancia, Filippo, Quick, Matthias, Uhlemann, Anne-Catrin, Sinnis, Photini, Fidock, David A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312498/ https://www.ncbi.nlm.nih.gov/pubmed/37398288 http://dx.doi.org/10.1101/2023.06.02.543338

Ejemplares similares

Mapping the genomic landscape of multidrug resistance in Plasmodium falciparum and its impact on parasite fitness
por: Mok, Sachel, et al.
Publicado: (2023)

Generation of Transmission-Competent Human Malaria Parasites with Chromosomally-Integrated Fluorescent Reporters
por: McLean, Kyle Jarrod, et al.
Publicado: (2019)

Overexpression of Plasmodium berghei ATG8 by Liver Forms Leads to Cumulative Defects in Organelle Dynamics and to Generation of Noninfectious Merozoites
por: Voss, Christiane, et al.
Publicado: (2016)

A mosquito salivary gland protein partially inhibits Plasmodium sporozoite cell traversal and transmission
por: Schleicher, Tyler R., et al.
Publicado: (2018)

Immune Regulation of Plasmodium Is Anopheles Species Specific and Infection Intensity Dependent
por: Simões, Maria L., et al.
Publicado: (2017)

Gametocytocidal Screen Identifies Novel Chemical Classes with Plasmodium falciparum Transmission Blocking Activity
por: Sanders, Natalie G., et al.
Publicado: (2014)

Comparative Analysis of Plasmodium falciparum Genotyping via SNP Detection, Microsatellite Profiling, and Whole-Genome Sequencing
por: Kanai, Mariko, et al.
Publicado: (2022)

A no film slot blot for the detection of developing P. falciparum oocysts in mosquitoes
por: Grabias, Bryan, et al.
Publicado: (2017)

Transmissibility of clinically relevant atovaquone-resistant Plasmodium falciparum by anopheline mosquitoes
por: Balta, Victoria A., et al.
Publicado: (2023)

Clinically relevant atovaquone-resistant human malaria parasites fail to transmit by mosquito
por: Balta, Victoria A., et al.
Publicado: (2023)

Emerging Southeast Asian PfCRT mutations confer Plasmodium falciparum resistance to the first-line antimalarial piperaquine
por: Ross, Leila S., et al.
Publicado: (2018)

Transcriptome analysis based detection of Plasmodium falciparum development in Anopheles stephensi mosquitoes
por: Oakley, Miranda S., et al.
Publicado: (2018)

Global Spread of Mutant PfCRT and Its Pleiotropic Impact on Plasmodium falciparum Multidrug Resistance and Fitness
por: Dhingra, Satish K., et al.
Publicado: (2019)

Chromobacterium Csp_P Reduces Malaria and Dengue Infection in Vector Mosquitoes and Has Entomopathogenic and In Vitro Anti-pathogen Activities
por: Ramirez, Jose Luis, et al.
Publicado: (2014)

Lack of Effect of Gluten Challenge on Fecal Microbiome in Patients With Celiac Disease and Non-Celiac Gluten Sensitivity
por: Nobel, Yael R., et al.
Publicado: (2021)

Long-acting injectable atovaquone nanomedicines for malaria prophylaxis
por: Bakshi, Rahul P., et al.
Publicado: (2018)

The ins and outs of sporozoite biology in the dermis
por: Hopp, Christine, et al.
Publicado: (2014)

Reply to Vanderberg, “Further Mechanisms and Locations in Which Antisporozoite Antibodies Neutralize Malaria Sporozoites”
por: Sinnis, Photini, et al.
Publicado: (2019)

Transport of antibody into the skin is only partially dependent upon the neonatal Fc-receptor
por: Nasir, Gibran, et al.
Publicado: (2023)

Globally prevalent PfMDR1 mutations modulate Plasmodium falciparum susceptibility to artemisinin-based combination therapies
por: Veiga, M. Isabel, et al.
Publicado: (2016)

Correction: Aberrant Sporogonic Development of Dmc1 (a Meiotic Recombinase) Deficient Plasmodium berghei Parasites
por: Mlambo, Godfree, et al.
Publicado: (2013)

Aberrant Sporogonic Development of Dmc1 (a Meiotic Recombinase) Deficient Plasmodium berghei Parasites
por: Mlambo, Godfree, et al.
Publicado: (2012)

Evidence for the early emergence of piperaquine-resistant Plasmodium falciparum malaria and modeling strategies to mitigate resistance
por: Small-Saunders, Jennifer L., et al.
Publicado: (2022)

Plasmodium falciparum resistance to artemisinin-based combination therapies
por: Ward, Kurt E, et al.
Publicado: (2022)

Intestinal Dysbiosis and Risk of Posttransplant Clostridioides difficile Infection in a Longitudinal Cohort of Liver Transplant Recipients
por: Gomez-Simmonds, Angela, et al.
Publicado: (2022)

Mutant PfCRT Can Mediate Piperaquine Resistance in African Plasmodium falciparum With Reduced Fitness and Increased Susceptibility to Other Antimalarials
por: Wicht, Kathryn J, et al.
Publicado: (2022)

Aquaglyceroporin PbAQP is required for efficient progression through the liver stage of Plasmodium infection
por: Promeneur, Dominique, et al.
Publicado: (2018)

Molecular Markers of Radiation Induced Attenuation in Intrahepatic Plasmodium falciparum Parasites
por: Oakley, Miranda S., et al.
Publicado: (2016)

Artemisinin-resistant K13 mutations rewire Plasmodium falciparum’s intra-erythrocytic metabolic program to enhance survival
por: Mok, Sachel, et al.
Publicado: (2021)

Salivary Microbiome Differences in Prepubertal Children With and Without Adrenal Androgen Excess
por: Wise-Oringer, Brittany K., et al.
Publicado: (2022)

Generation of a mutator parasite to drive resistome discovery in Plasmodium falciparum
por: Kümpornsin, Krittikorn, et al.
Publicado: (2023)

C-type lectin 4 regulates broad-spectrum melanization-based refractoriness to malaria parasites
por: Simões, Maria L., et al.
Publicado: (2022)

Targeting the Cell Stress Response of Plasmodium falciparum to Overcome Artemisinin Resistance
por: Dogovski, Con, et al.
Publicado: (2015)

Plasmodium sporozoites trickle out of the injection site
por: Yamauchi, Lucy Megumi, et al.
Publicado: (2007)

Plasmodium sporozoites trickle out of the injection site
por: Yamauchi, Lucy Megumi, et al.
Publicado: (2007)

The Plasmodium circumsporozoite protein is proteolytically processed during cell invasion
por: Coppi, Alida, et al.
Publicado: (2005)

Plasmodium Protease ROM1 Is Important for Proper Formation of the Parasitophorous Vacuole
por: Vera, Iset Medina, et al.
Publicado: (2011)

Dietary tryptophan deficiency promotes gut RORγt(+) Treg cells at the expense of Gata3(+) Treg cells and alters commensal microbiota metabolism
por: Rankin, Lucille C., et al.
Publicado: (2023)

Experimental determination of the force of malaria infection reveals a non-linear relationship to mosquito sporozoite loads
por: Aleshnick, Maya, et al.
Publicado: (2020)

A Variant PfCRT Isoform Can Contribute to Plasmodium falciparum Resistance to the First-Line Partner Drug Piperaquine
por: Dhingra, Satish K., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_e1aqul9c5qao3vn2pqmrk9iqpm